Forty-seven Italian patients suffering from hepatocellular carcinoma (HCC) and 58 patients with chronic active hepatitis (CAH) were screened for α 1-antitrypsin (α 1AT) levels and types and compared with a previously screened healthy Italian population. Serum α 1AT concentrations were significantly raised among the HCC patients compared to the controls, whereas the CAH group showed no differences. The incidence of non-M phenotypes (MS, MZ and S) is significantly higher in patients with HCC than in the CAH group and the controls. The mean age of HCC patients with a non-M phenotype is significantly lower than the mean age of HCC patients with an M phenotype.
Alpha 1-antitrypsin in patients with hepatocellular carcinoma and chronic active hepatitis / S. Fargion, E.C. Klasen, F. Lalatta, G. Sangalli, M. Tommasini, G. Fiorelli. - In: CLINICAL GENETICS. - ISSN 0009-9163. - 19:2(1981 Feb), pp. 134-139.
Alpha 1-antitrypsin in patients with hepatocellular carcinoma and chronic active hepatitis
S. FargionPrimo
;G. Sangalli;G. FiorelliUltimo
1981
Abstract
Forty-seven Italian patients suffering from hepatocellular carcinoma (HCC) and 58 patients with chronic active hepatitis (CAH) were screened for α 1-antitrypsin (α 1AT) levels and types and compared with a previously screened healthy Italian population. Serum α 1AT concentrations were significantly raised among the HCC patients compared to the controls, whereas the CAH group showed no differences. The incidence of non-M phenotypes (MS, MZ and S) is significantly higher in patients with HCC than in the CAH group and the controls. The mean age of HCC patients with a non-M phenotype is significantly lower than the mean age of HCC patients with an M phenotype.Pubblicazioni consigliate
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