Forty-seven Italian patients suffering from hepatocellular carcinoma (HCC) and 58 patients with chronic active hepatitis (CAH) were screened for α 1-antitrypsin (α 1AT) levels and types and compared with a previously screened healthy Italian population. Serum α 1AT concentrations were significantly raised among the HCC patients compared to the controls, whereas the CAH group showed no differences. The incidence of non-M phenotypes (MS, MZ and S) is significantly higher in patients with HCC than in the CAH group and the controls. The mean age of HCC patients with a non-M phenotype is significantly lower than the mean age of HCC patients with an M phenotype.

Alpha 1-antitrypsin in patients with hepatocellular carcinoma and chronic active hepatitis / S. Fargion, E.C. Klasen, F. Lalatta, G. Sangalli, M. Tommasini, G. Fiorelli. - In: CLINICAL GENETICS. - ISSN 0009-9163. - 19:2(1981 Feb), pp. 134-139.

Alpha 1-antitrypsin in patients with hepatocellular carcinoma and chronic active hepatitis

S. Fargion
Primo
;
G. Sangalli;G. Fiorelli
Ultimo
1981-02

Abstract

Forty-seven Italian patients suffering from hepatocellular carcinoma (HCC) and 58 patients with chronic active hepatitis (CAH) were screened for α 1-antitrypsin (α 1AT) levels and types and compared with a previously screened healthy Italian population. Serum α 1AT concentrations were significantly raised among the HCC patients compared to the controls, whereas the CAH group showed no differences. The incidence of non-M phenotypes (MS, MZ and S) is significantly higher in patients with HCC than in the CAH group and the controls. The mean age of HCC patients with a non-M phenotype is significantly lower than the mean age of HCC patients with an M phenotype.
Adult ; Aged ; Carcinoma, Hepatocellular ; Chronic Disease ; Gene Frequency ; Hepatitis ; Humans ; Liver Neoplasms ; Middle Aged ; Phenotype ; alpha 1-Antitrypsin
Settore MED/09 - Medicina Interna
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/234915
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