IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca
IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.
AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishThe High-Mobility Group Box (HMGB) proteins are highly abundant proteins with both nuclear and extracellular roles in key biological processes. In mammals, three family members are present: HMGB1, HMGB2 and HMGB3. We characterized the HMGB family in zebrafish and report a detailed phylogenetic analysis of HMGB proteins. The B1, B2, and B3 subfamilies are present in cartilaginous fish, bony fish, and tetrapods, while jawless fish sequences emerge as basal to the gene family expansion. Two co-orthologs of each mammalian HMGB gene are present in zebrafish. All six zebrafish hmgb genes are maternally expressed, but huge differences in expression levels exist during embryonic development. The hmgb2a/hmgb2b genes are the most highly expressed, while hmgb3b is expressed at the lowest level. Remarkably, hmgb3 genes are not present in fugu, medaka, Tetraodon and stickleback. Our analysis highlights substantial overlaps, but also subtle differences and specificities in the expression patterns of the zebrafish hmgb genes.
The HMGB protein gene family in zebrafish : evolution and embryonic expression patterns / S. Moleri, G. Cappellano, G. Gaudenzi, S. Cermenati, F. Cotelli, D.S. Horner, M. Beltrame. - In: GENE EXPRESSION PATTERNS. - ISSN 1567-133X. - 11:1/2(2011), pp. 3-11.
| Titolo: | The HMGB protein gene family in zebrafish : evolution and embryonic expression patterns |
| Autori: | MOLERI, SILVIA (Primo) CAPPELLANO, GIUSEPPE (Secondo) BELTRAME, MONICA DANIELA (Ultimo) |
| Parole Chiave: | high-mobility group; high-mobility group box; gene family; phylogenetic analysis; molecular evolution; gene expression; development; embryonic development; vertebrates; fish; danio rerio; in situ hybridization; synteny; chromatin; transcription; recombination; repair; inflammation; innate immunity; tissue regeneration |
| Settore Scientifico Disciplinare: | Settore BIO/11 - Biologia Molecolare Settore BIO/18 - Genetica Settore BIO/06 - Anatomia Comparata e Citologia |
| Data di pubblicazione: | 2011 |
| Rivista: | |
| Tipologia: | Article (author) |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.gep.2010.08.006 |
| Appare nelle tipologie: | 01 - Articolo su periodico |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 1-s2.0-S1567133X10000852-main.pdf | Publisher's version/PDF | Administrator Richiedi una copia |
Copyright © 2020