BACKGROUND: Candida bloodstream infections (BSI) represent an important problem in Intensive Care Units (ICUs). The epidemiology of candidemia is changing with an increase in the proportion of Candida (C.) non-albicans. OBJECTIVES: An Italian 2-year observational survey on ICU was conducted to evaluate the species distribution and possible differences between BSI caused by C. albicans and C. non-albicans. For comparative purposes, we performed a European literature-based review to evaluate distribution and frequency of Candida spp. causing ICU candidemia, during the period 2000-2013. MATERIALS AND METHODS: This laboratory-based survey involved 15 microbiology centers (GISIA-3 study). All candidemia episodes in adult patients were considered. Data were prospectively collected from 2007 to 2008. PubMed was searched for peer-reviewed articles. RESULTS: In total, 462 candidemia episodes were collected. C. albicans accounted for 49.4% of the isolates, followed by C. parapsilosis (26.2%) and C. glabrata (10.4%). Mortality was higher in patients with C. non-albicans than C. albicans (47.3% vs. 32.4 %, p > 0.05). Among risk factors, parenteral nutrition was more common (p = 0.02) in non-albicans candidemia, while surgery was more frequent (p = 0.02) in C. albicans candidemia. Twenty-four relevant articles were identified. C. albicans was the predominant species in almost all studies (range 37.9% -76.3%). C. glabrata was commonly isolated in the German-speaking countries, France, UK and North Europe; C. parapsilosis in Turkey, Greece and Spain. CONCLUSIONS: Although C. non-albicans BSI is increasing, our study shows that C. albicans is still the predominant species in ICU candidemia. There are differences in the epidemiology of Candida BSI among European countries, with a prevalence of C. glabrata and C. parapsilosis in Northern and Southern countries, respectively.

Candidemia in intensive care unit : a nationwide prospective observational survey (GISIA-3 study) and review of the European literature from 2000 through 2013 / M.T. Montagna, G. Lovero, E. Borghi, G. Amato, S. Andreoni, L. Campion, G. Lo Cascio, G. Lombardi, F. Luzzaro, E. Manso, M. Mussap, P. Pecile, S. Perin, E. Tangorra, M. Tronci, R. Iatta, G. Morace. - In: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES. - ISSN 2284-0729. - 18:5(2014 Mar), pp. 661-674.

Candidemia in intensive care unit : a nationwide prospective observational survey (GISIA-3 study) and review of the European literature from 2000 through 2013

E. Borghi;G. Morace
Ultimo
2014

Abstract

BACKGROUND: Candida bloodstream infections (BSI) represent an important problem in Intensive Care Units (ICUs). The epidemiology of candidemia is changing with an increase in the proportion of Candida (C.) non-albicans. OBJECTIVES: An Italian 2-year observational survey on ICU was conducted to evaluate the species distribution and possible differences between BSI caused by C. albicans and C. non-albicans. For comparative purposes, we performed a European literature-based review to evaluate distribution and frequency of Candida spp. causing ICU candidemia, during the period 2000-2013. MATERIALS AND METHODS: This laboratory-based survey involved 15 microbiology centers (GISIA-3 study). All candidemia episodes in adult patients were considered. Data were prospectively collected from 2007 to 2008. PubMed was searched for peer-reviewed articles. RESULTS: In total, 462 candidemia episodes were collected. C. albicans accounted for 49.4% of the isolates, followed by C. parapsilosis (26.2%) and C. glabrata (10.4%). Mortality was higher in patients with C. non-albicans than C. albicans (47.3% vs. 32.4 %, p > 0.05). Among risk factors, parenteral nutrition was more common (p = 0.02) in non-albicans candidemia, while surgery was more frequent (p = 0.02) in C. albicans candidemia. Twenty-four relevant articles were identified. C. albicans was the predominant species in almost all studies (range 37.9% -76.3%). C. glabrata was commonly isolated in the German-speaking countries, France, UK and North Europe; C. parapsilosis in Turkey, Greece and Spain. CONCLUSIONS: Although C. non-albicans BSI is increasing, our study shows that C. albicans is still the predominant species in ICU candidemia. There are differences in the epidemiology of Candida BSI among European countries, with a prevalence of C. glabrata and C. parapsilosis in Northern and Southern countries, respectively.
No
English
Candida spp; Candidemia; Intensive Care Unit; Literature review; Yeast infections
Settore MED/07 - Microbiologia e Microbiologia Clinica
Articolo
Esperti anonimi
Ricerca applicata
Pubblicazione scientifica
mar-2014
Verduci
18
5
661
674
14
Pubblicato
Periodico con rilevanza internazionale
Aderisco
info:eu-repo/semantics/article
Candidemia in intensive care unit : a nationwide prospective observational survey (GISIA-3 study) and review of the European literature from 2000 through 2013 / M.T. Montagna, G. Lovero, E. Borghi, G. Amato, S. Andreoni, L. Campion, G. Lo Cascio, G. Lombardi, F. Luzzaro, E. Manso, M. Mussap, P. Pecile, S. Perin, E. Tangorra, M. Tronci, R. Iatta, G. Morace. - In: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES. - ISSN 2284-0729. - 18:5(2014 Mar), pp. 661-674.
open
Prodotti della ricerca::01 - Articolo su periodico
17
262
Article (author)
no
M.T. Montagna, G. Lovero, E. Borghi, G. Amato, S. Andreoni, L. Campion, G. Lo Cascio, G. Lombardi, F. Luzzaro, E. Manso, M. Mussap, P. Pecile, S. Peri...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/233195
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