Non-covalent (NP-1/3) and covalent (NP-A-1/3) pro-apoptotic SPION-Smac mimetic nano-conjugates antitumor agents are reported. The solution synthesis of key Smac mimetics, their support onto SPIONs through non-covalent adsorption (NP-1/3) or APTES-mediated covalent binding (NP-A-1/3), the analytical characterization of SPION-Smac mimetic conjugates, their target affinity in cell-free assays, and their cytotoxicity against tumor cells are thoroughly described.
SPION-Smac mimetic nano-conjugates: putative pro-apoptotic agents in oncology / P. Seneci, M. Rizzi, L. Ballabio, D. Lecis, A. Conti, C. Carrara, E. Licandro. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 24:10(2014), pp. 2374-2378. [10.1016/j.bmcl.2014.03.048]
SPION-Smac mimetic nano-conjugates: putative pro-apoptotic agents in oncology
P. Seneci
;A. Conti;C. CarraraPenultimo
;E. LicandroUltimo
2014
Abstract
Non-covalent (NP-1/3) and covalent (NP-A-1/3) pro-apoptotic SPION-Smac mimetic nano-conjugates antitumor agents are reported. The solution synthesis of key Smac mimetics, their support onto SPIONs through non-covalent adsorption (NP-1/3) or APTES-mediated covalent binding (NP-A-1/3), the analytical characterization of SPION-Smac mimetic conjugates, their target affinity in cell-free assays, and their cytotoxicity against tumor cells are thoroughly described.
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