Mitochondria have small mitochondrial DNA (mtDNA) molecules independent from the nuclear DNA, a separate epigenetic machinery that generates mtDNA methylation, and are primary sources of oxidative-stress generation in response to exogenous environments. However, no study has yet investigated whether mitochondrial DNA methylation is sensitive to pro-oxidant environmental exposures.

Effects of airborne pollutants on mitochondrial DNA methylation / H.M. Byun, T. Panni, V. Motta, L. Hou, F. Nordio, P. Apostoli, P.A. Bertazzi, A. Baccarelli. - In: PARTICLE AND FIBRE TOXICOLOGY. - ISSN 1743-8977. - 2013:1(2013 May), pp. 18.10-18.18.

Effects of airborne pollutants on mitochondrial DNA methylation

V. Motta;F. Nordio;P.A. Bertazzi;A. Baccarelli
2013-05

Abstract

Mitochondria have small mitochondrial DNA (mtDNA) molecules independent from the nuclear DNA, a separate epigenetic machinery that generates mtDNA methylation, and are primary sources of oxidative-stress generation in response to exogenous environments. However, no study has yet investigated whether mitochondrial DNA methylation is sensitive to pro-oxidant environmental exposures.
Air pollutants; DNA methylation; Mitochondria
Settore MED/44 - Medicina del Lavoro
PARTICLE AND FIBRE TOXICOLOGY
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/231959
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