Mitochondria have small mitochondrial DNA (mtDNA) molecules independent from the nuclear DNA, a separate epigenetic machinery that generates mtDNA methylation, and are primary sources of oxidative-stress generation in response to exogenous environments. However, no study has yet investigated whether mitochondrial DNA methylation is sensitive to pro-oxidant environmental exposures.
Effects of airborne pollutants on mitochondrial DNA methylation / H.M. Byun, T. Panni, V. Motta, L. Hou, F. Nordio, P. Apostoli, P.A. Bertazzi, A. Baccarelli. - In: PARTICLE AND FIBRE TOXICOLOGY. - ISSN 1743-8977. - 2013:1(2013 May), pp. 18.10-18.18. [10.1186/1743-8977-10-18]
Effects of airborne pollutants on mitochondrial DNA methylation
V. Motta;F. Nordio;P.A. Bertazzi;A. BaccarelliUltimo
2013
Abstract
Mitochondria have small mitochondrial DNA (mtDNA) molecules independent from the nuclear DNA, a separate epigenetic machinery that generates mtDNA methylation, and are primary sources of oxidative-stress generation in response to exogenous environments. However, no study has yet investigated whether mitochondrial DNA methylation is sensitive to pro-oxidant environmental exposures.
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