Ultrasonography (US) is a validated method to accurately measure abdominal visceral adipose thickness (VAT), a parameter related to the risk of cardiovascular diseases but whose predictive cut-off values for the metabolic syndrome (MS) are unavailable. This study aimed to 1) investigate the association of VAT to MS components; 2) identify predictive cut-off values of MS risk according to sex and age in a large Caucasian sample. Anthropometry, blood pressure, fasting plasma glucose (PG), HDL-cholesterol, triglycerides and VAT (distance from aortic anterior wall to rectus abdominis posterior surface measured above the umbilicus by US) were assessed in 3431 subjects (71,4% females, 46,8 ± 13,4 years). MS was diagnosed by IDF criteria (2005). MS prevalence was 34,6% (54,2% in men and 26,8% in women). VAT was positively associated to waist (r2=0,645 p<0,001), triglycerides (r2=0,134 p<0,001), PG (r2=0,14 p<0,001), systolic (r2=0,24 p<0,001) and diastolic pressures (r2=0,185 p<0,001), and negatively to HDL-cholesterol (r2=0,153 p<0,001). After ROC curve analysis, the optimal VAT cut-off points for MS prediction were 7,6cm in males (sensitivity: 68%, specificity: 77%, AUC: 0,78, p<0,001) and 5,3cm in females (sensitivity: 68%, specificity: 77%, AUC: 0,78, p<0,001), that were increased with age strata in both genders. In conclusion, intra-abdominal fat thickness was related to MS and to all of its components with predictive cut-off values greater in males and in the elderly.

Abdominal visceral adiposity measured by ultrasonography and risk of metabolic syndrome and its components : identification of predictive cut-off of risk / S. Bertoli, A. Leone, L. Vignati, A. Spadafranca, C. Cappelletti, A. Battezzati. ((Intervento presentato al convegno Società Italiana di Fisiologia tenutosi a Verona nel 2012.

Abdominal visceral adiposity measured by ultrasonography and risk of metabolic syndrome and its components : identification of predictive cut-off of risk

S. Bertoli;A. Leone;L. Vignati;A. Spadafranca;C. Cappelletti;A. Battezzati
2012

Abstract

Ultrasonography (US) is a validated method to accurately measure abdominal visceral adipose thickness (VAT), a parameter related to the risk of cardiovascular diseases but whose predictive cut-off values for the metabolic syndrome (MS) are unavailable. This study aimed to 1) investigate the association of VAT to MS components; 2) identify predictive cut-off values of MS risk according to sex and age in a large Caucasian sample. Anthropometry, blood pressure, fasting plasma glucose (PG), HDL-cholesterol, triglycerides and VAT (distance from aortic anterior wall to rectus abdominis posterior surface measured above the umbilicus by US) were assessed in 3431 subjects (71,4% females, 46,8 ± 13,4 years). MS was diagnosed by IDF criteria (2005). MS prevalence was 34,6% (54,2% in men and 26,8% in women). VAT was positively associated to waist (r2=0,645 p<0,001), triglycerides (r2=0,134 p<0,001), PG (r2=0,14 p<0,001), systolic (r2=0,24 p<0,001) and diastolic pressures (r2=0,185 p<0,001), and negatively to HDL-cholesterol (r2=0,153 p<0,001). After ROC curve analysis, the optimal VAT cut-off points for MS prediction were 7,6cm in males (sensitivity: 68%, specificity: 77%, AUC: 0,78, p<0,001) and 5,3cm in females (sensitivity: 68%, specificity: 77%, AUC: 0,78, p<0,001), that were increased with age strata in both genders. In conclusion, intra-abdominal fat thickness was related to MS and to all of its components with predictive cut-off values greater in males and in the elderly.
Settore BIO/09 - Fisiologia
http://www.blackwellpublishing.com/aphmeeting/abstract.asp?MeetingID=792&id=104057
Centro Internazionale per lo Studio della Composizione Corporea ICANS
Abdominal visceral adiposity measured by ultrasonography and risk of metabolic syndrome and its components : identification of predictive cut-off of risk / S. Bertoli, A. Leone, L. Vignati, A. Spadafranca, C. Cappelletti, A. Battezzati. ((Intervento presentato al convegno Società Italiana di Fisiologia tenutosi a Verona nel 2012.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/231830
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