Short-term exposures to fine (<2.5 μm aerodynamic diameter) ambient particulate-matter (PM) have been related with increased blood pressure (BP) in controlled-human exposure and community-based studies. However, whether coarse (2.5 to 10 μm) PM exposure increases BP is uncertain. Recent observational studies have linked PM exposures with blood DNA hypomethylation, an epigenetic alteration that activates inflammatory and vascular responses. No experimental evidence is available to confirm those observational data and demonstrate the relations between PM, hypomethylation, and BP.
|Titolo:||DNA hypomethylation, ambient particulate matter, and increased blood pressure : findings from controlled human exposure experiments|
BACCARELLI, ANDREA (Ultimo)
|Parole Chiave:||DNA methylation ; air pollution ; blood pressure ; epigenetics ; mediation ; Blood Pressure ; DNA Methylation ; Environmental Exposure ; Adolescent ; Adult ; Cross-Over Studies ; Double-Blind Method ; Female ; Humans ; Hypertension ; Male ; Middle Aged ; Particulate Matter ; Young Adult|
|Settore Scientifico Disciplinare:||Settore MED/44 - Medicina del Lavoro|
|Data di pubblicazione:||giu-2013|
|Digital Object Identifier (DOI):||10.1161/JAHA.113.000212|
|Appare nelle tipologie:||01 - Articolo su periodico|