Background & aims: This 6-month prospective, single-arm observational study was designed to assess the effects of the KD on the nutritional status, resting energy expenditure (REE), and substrate oxidation in patients with drug-resistant epilepsy. Methods: Eighteen patients with medically refractory epilepsy underwent assessment of body composition, REE, and substrate oxidation rates before and after 6 months of MD. Results: Compared with baseline, there were no statistically significant differences at 6 months in terms of height, weight, BMI z-scores, and REE. However, the respiratory quotient decreased significantly (from 0.80 +/- 0.06 to 0.72 +/- 0.05,p < 0.001) whereas fat oxidation was significantly increased (from 50.9 +/- 25.2 mg/min to 97.5 +/- 25.7 mg/min, p < 0.001). Interestingly, we found that the increase in fat oxidation was the main independent predictor of the reduction in seizure frequency (beta = -0.97, t = -6.3, p < 0.05). Conclusions: Administering a MD for 6 months in patients with medically refractory epilepsy increases fat oxidation and decreases the respiratory quotient, without appreciable changes in REE.

Effects of the ketogenic diet on nutritional status, resting energy expenditure, and substrate oxidation in patients with medically refractory epilepsy: a 6-month prospective observational study / A. Tagliabue, S. Bertoli, C. Trentani, P. Borrelli, P. Veggiotti. - In: CLINICAL NUTRITION. - ISSN 0261-5614. - 31:2(2012 Apr), pp. 246-249.

Effects of the ketogenic diet on nutritional status, resting energy expenditure, and substrate oxidation in patients with medically refractory epilepsy: a 6-month prospective observational study

S. Bertoli;P. Veggiotti
2012-04

Abstract

Background & aims: This 6-month prospective, single-arm observational study was designed to assess the effects of the KD on the nutritional status, resting energy expenditure (REE), and substrate oxidation in patients with drug-resistant epilepsy. Methods: Eighteen patients with medically refractory epilepsy underwent assessment of body composition, REE, and substrate oxidation rates before and after 6 months of MD. Results: Compared with baseline, there were no statistically significant differences at 6 months in terms of height, weight, BMI z-scores, and REE. However, the respiratory quotient decreased significantly (from 0.80 +/- 0.06 to 0.72 +/- 0.05,p < 0.001) whereas fat oxidation was significantly increased (from 50.9 +/- 25.2 mg/min to 97.5 +/- 25.7 mg/min, p < 0.001). Interestingly, we found that the increase in fat oxidation was the main independent predictor of the reduction in seizure frequency (beta = -0.97, t = -6.3, p < 0.05). Conclusions: Administering a MD for 6 months in patients with medically refractory epilepsy increases fat oxidation and decreases the respiratory quotient, without appreciable changes in REE.
Ketogenic diet; Drug-resistant epilepsy; Resting energy expenditure; Fat oxidation; Respiratory quotient
Settore BIO/09 - Fisiologia
Settore MED/13 - Endocrinologia
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
Settore MED/39 - Neuropsichiatria Infantile
CLINICAL NUTRITION
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/231730
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