Lipoxygenases play a major role in the neuropathology of Alzheimer’s disease (AD), even though the underlying mechanisms are as yet poorly understood. Here, we studied the epigenetic regulation of 5-lipoxygenase (5-LOX) in peripheral blood mononuclear cells of subjects with late-onset AD and age-matched controls. We found a significant increase in 5-LOX gene expression in AD subjects compared to healthy controls, paralleled by increased 5-LOX protein and leukotriene B4, the 5-LOX product. In addition, a consistent reduction in DNA methylation at 5-LOX gene promoter was documented in AD versus healthy subjects. Taken together, our findings further support a role for 5-LOX in vulnerability to neurodegeneration.
Involvement of 5-lipoxygenase in Alzheimer's disease : a role for DNA methylation / A. Di Francesco, B. Arosio, C. Gussago, E. Dainese, D. Mari, C. D'Addario, M. Maccarrone. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 37:1(2013 Jan 01), pp. 3-8. [10.3233/JAD-130506]
Involvement of 5-lipoxygenase in Alzheimer's disease : a role for DNA methylation
B. Arosio;C. Gussago;D. Mari;
2013
Abstract
Lipoxygenases play a major role in the neuropathology of Alzheimer’s disease (AD), even though the underlying mechanisms are as yet poorly understood. Here, we studied the epigenetic regulation of 5-lipoxygenase (5-LOX) in peripheral blood mononuclear cells of subjects with late-onset AD and age-matched controls. We found a significant increase in 5-LOX gene expression in AD subjects compared to healthy controls, paralleled by increased 5-LOX protein and leukotriene B4, the 5-LOX product. In addition, a consistent reduction in DNA methylation at 5-LOX gene promoter was documented in AD versus healthy subjects. Taken together, our findings further support a role for 5-LOX in vulnerability to neurodegeneration.Pubblicazioni consigliate
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