Lipoxygenases play a major role in the neuropathology of Alzheimer’s disease (AD), even though the underlying mechanisms are as yet poorly understood. Here, we studied the epigenetic regulation of 5-lipoxygenase (5-LOX) in peripheral blood mononuclear cells of subjects with late-onset AD and age-matched controls. We found a significant increase in 5-LOX gene expression in AD subjects compared to healthy controls, paralleled by increased 5-LOX protein and leukotriene B4, the 5-LOX product. In addition, a consistent reduction in DNA methylation at 5-LOX gene promoter was documented in AD versus healthy subjects. Taken together, our findings further support a role for 5-LOX in vulnerability to neurodegeneration.

Involvement of 5-lipoxygenase in Alzheimer's disease : a role for DNA methylation / A. Di Francesco, B. Arosio, C. Gussago, E. Dainese, D. Mari, C. D'Addario, M. Maccarrone. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 37:1(2013 Jan 01), pp. 3-8. [10.3233/JAD-130506]

Involvement of 5-lipoxygenase in Alzheimer's disease : a role for DNA methylation

B. Arosio;C. Gussago;D. Mari;
2013

Abstract

Lipoxygenases play a major role in the neuropathology of Alzheimer’s disease (AD), even though the underlying mechanisms are as yet poorly understood. Here, we studied the epigenetic regulation of 5-lipoxygenase (5-LOX) in peripheral blood mononuclear cells of subjects with late-onset AD and age-matched controls. We found a significant increase in 5-LOX gene expression in AD subjects compared to healthy controls, paralleled by increased 5-LOX protein and leukotriene B4, the 5-LOX product. In addition, a consistent reduction in DNA methylation at 5-LOX gene promoter was documented in AD versus healthy subjects. Taken together, our findings further support a role for 5-LOX in vulnerability to neurodegeneration.
Settore BIO/11 - Biologia Molecolare
Settore BIO/13 - Biologia Applicata
1-gen-2013
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/230974
Citazioni
  • ???jsp.display-item.citation.pmc??? 11
  • Scopus 41
  • ???jsp.display-item.citation.isi??? 33
social impact