Primary immunodeficiencies (PIDs) are rare diseases characterized by an increased susceptibility to infections. Early diagnosis and appropriate treatment are critical for reducing morbidity and mortality. Based on available data, the efficacy of antibiotic administration for the prophylaxis of infections remains uncertain, and recommendations supporting this practice are poor. The use of antimicrobial prophylaxis is mainly based on single institution-specific experience without controlled measurements of patient safety and quality health outcomes. To address this issue an Italian Network on Primary Immunodeficiencies (IPINet) has been set up in 1999 within the Italian Association of Pediatric Hematology and Oncology (AIEOP) to increase the awareness of these disorders among physicians. Further, diagnostic and treatment guideline recommendations have been established to standardize the best clinical assistance to all patients, including antibiotic prophylaxis, and for a national epidemiologic monitoring of PIDs. The aim of this review is not only to give a scientific update on the use of antimicrobial prophylaxis in selected congenital immunological disorders but also to draw a picture of this practice in the context of the Italian Primary Immunodeficiency Network (IPINet). Controlled multicenter studies are necessary to establish if, when and how you should start an efficacious antimicrobial prophylaxis.
Anti-infective prophylaxis for primary immunodeficiencies : what is done in Italian Primary Immunodeficiency Network centers (IPINet) and review of the literature / V. Moschese, B. Martire, A. Soresina, L. Chini, S. Graziani, E. Monteferrario, R. Bacchetta, C. Cancrini, M. Fiorilli, E. Gambineri, A. Pession, C. Pignata, I. Quinti, R. Rondelli, P. Rossi, A.G. Ugazio, A. Plebani, M.C. Pietrogrande. - In: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS. - ISSN 0393-974X. - 27:4(2013), pp. 935-946.
|Titolo:||Anti-infective prophylaxis for primary immunodeficiencies : what is done in Italian Primary Immunodeficiency Network centers (IPINet) and review of the literature|
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
|Data di pubblicazione:||2013|
|Appare nelle tipologie:||01 - Articolo su periodico|