Here, we describe data obtained from transcriptome profiling of human cell lines and intestinal cells of a murine model upon exposure and colonization, respectively, with Bifidobacterium bifidum PRL2010. Significant changes were detected in the transcription of genes that are known to be involved in innate immunity. Furthermore, results from enzyme-linked immunosorbent assays (ELISAs) showed that exposure to B. bifidum PRL2010 causes enhanced production of interleukin 6 (IL-6) and IL-8 cytokines, presumably through NFκB activation. The obtained global transcription profiles strongly suggest that Bifidobacterium bifidum PRL2010 modulates the innate immune response of the host.

Bifidobacterium bifidum PRL2010 Modulates the Host Innate Immune Response / F. Turroni, V. Taverniti, P. Ruas Madiedo, S. Duranti, S. Guglielmetti, G.A. Lugli, L. Gioiosa, P. Palanza, A. Margolles, D. Van Sinderen, M. Ventura. - In: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. - ISSN 0099-2240. - 80:2(2014 Jan), pp. 730-740. [10.1128/AEM.03313-13]

Bifidobacterium bifidum PRL2010 Modulates the Host Innate Immune Response

V. Taverniti;S. Guglielmetti;
2014-01

Abstract

Here, we describe data obtained from transcriptome profiling of human cell lines and intestinal cells of a murine model upon exposure and colonization, respectively, with Bifidobacterium bifidum PRL2010. Significant changes were detected in the transcription of genes that are known to be involved in innate immunity. Furthermore, results from enzyme-linked immunosorbent assays (ELISAs) showed that exposure to B. bifidum PRL2010 causes enhanced production of interleukin 6 (IL-6) and IL-8 cytokines, presumably through NFκB activation. The obtained global transcription profiles strongly suggest that Bifidobacterium bifidum PRL2010 modulates the innate immune response of the host.
Heat-shock proteins; intestinal epithelial-cells; CACO-2 cells; gene-expression; in-vitro; lactobacillus-acidophilus; colorectal-carcinoma; ulcerative-colitis; dendritic cells; genome analysis
Settore AGR/16 - Microbiologia Agraria
Settore BIO/19 - Microbiologia Generale
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/230201
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