The advanced glycoxidation end products (AGEs) and lipoxidation end products (ALEs) contribute to the development of diabetic complications and of other pathologies. The review discusses the possibilities of counteracting the formation and stimulating the degradation of these species by pharmaceuticals and natural compounds. The review discusses inhibitors of ALE and AGE formation, cross-link breakers, ALE/AGE elimination by enzymes and proteolytic systems, receptors for advanced glycation end products (RAGEs) and blockade of the ligand-RAGE axis.
Molecular strategies to prevent, inhibit and degrade advanced glycoxidation and advanced lipoxidation end products / G. Aldini, G. Vistoli, M. Stefek, N. Chondrogianni, T. Grune, J. Sereikaite, I. Sadowska-Bartosz, G. Bartosz. - In: FREE RADICAL RESEARCH. - ISSN 1071-5762. - 47:Suppl. 1(2013 May 07), pp. 93-137. [10.3109/10715762.2013.792926]
Molecular strategies to prevent, inhibit and degrade advanced glycoxidation and advanced lipoxidation end products
G. AldiniPrimo
;G. VistoliSecondo
;
2013
Abstract
The advanced glycoxidation end products (AGEs) and lipoxidation end products (ALEs) contribute to the development of diabetic complications and of other pathologies. The review discusses the possibilities of counteracting the formation and stimulating the degradation of these species by pharmaceuticals and natural compounds. The review discusses inhibitors of ALE and AGE formation, cross-link breakers, ALE/AGE elimination by enzymes and proteolytic systems, receptors for advanced glycation end products (RAGEs) and blockade of the ligand-RAGE axis.File | Dimensione | Formato | |
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