Pulsatile release capsules made of a swellable/ erodible polymer (HPC), prepared by injection molding, were preliminarily evaluated as substrates in coating processes. The feasibility of the process was demonstrated with Eudragit® L 30 D-55 by comparing the application of the same coating suspension onto conventional gelatin and HPMC capsules. The gastroresistant capsular devices obtained showed promising results for the development of a time-controlled colonic drug delivery system.
Gastroresistant coating of HPC capsules prepared by Injection-Molding / E. Macchi, L. Zema, A. Gazzaniga, L.A. Felton - In: Proceedings of the 2013 CRS Annual Meeting & Exposition[s.l] : CRS (Controlled Release Society), 2013 Jul. (( Intervento presentato al 40. convegno Annual Meeting Controlled Release Society tenutosi a Honolulu nel 2013.
Gastroresistant coating of HPC capsules prepared by Injection-Molding
E. Macchi;L. Zema;A. GazzanigaPenultimo
;
2013
Abstract
Pulsatile release capsules made of a swellable/ erodible polymer (HPC), prepared by injection molding, were preliminarily evaluated as substrates in coating processes. The feasibility of the process was demonstrated with Eudragit® L 30 D-55 by comparing the application of the same coating suspension onto conventional gelatin and HPMC capsules. The gastroresistant capsular devices obtained showed promising results for the development of a time-controlled colonic drug delivery system.
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