A short and efficient synthesis of the novel cytotoxic natural product berkeleyamide A, isolated from a deep-water Penicillium rubrum, has been accomplished. L-Leucinol was used as the only chiral starting material. A diastereoselective aldol condensation is the key step in the synthesis.
Total Synthesis of Berkeleyamide A and its 10-epi Isomer / N.S. Chakor, S. Dallavalle, L. Scaglioni, L. Merlini. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - 2010:32(2010), pp. 6217-6223. [10.1002/ejoc.201000914]
Total Synthesis of Berkeleyamide A and its 10-epi Isomer
N.S. Chakor;S. Dallavalle;L. ScaglioniPenultimo
;L. Merlini
2010
Abstract
A short and efficient synthesis of the novel cytotoxic natural product berkeleyamide A, isolated from a deep-water Penicillium rubrum, has been accomplished. L-Leucinol was used as the only chiral starting material. A diastereoselective aldol condensation is the key step in the synthesis.
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