A short and efficient synthesis of the novel cytotoxic natural product berkeleyamide A, isolated from a deep-water Penicillium rubrum, has been accomplished. L-Leucinol was used as the only chiral starting material. A diastereoselective aldol condensation is the key step in the synthesis.

Total Synthesis of Berkeleyamide A and its 10-epi Isomer / N.S. Chakor, S. Dallavalle, L. Scaglioni, L. Merlini. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - 2010:32(2010), pp. 6217-6223. [10.1002/ejoc.201000914]

Total Synthesis of Berkeleyamide A and its 10-epi Isomer

N.S. Chakor;S. Dallavalle;L. Scaglioni;L. Merlini
2010

Abstract

A short and efficient synthesis of the novel cytotoxic natural product berkeleyamide A, isolated from a deep-water Penicillium rubrum, has been accomplished. L-Leucinol was used as the only chiral starting material. A diastereoselective aldol condensation is the key step in the synthesis.
Natural products ; Total synthesis ; Diastereoselectivity ; Aldol reactions
Settore CHIM/06 - Chimica Organica
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/227110
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