Oxidation of 1-alkyl-1,4-butanediols with Acetobacter aceti MIM 2000/28 gave the corresponding γ-lactones in good yields. The biotransformation occurred with intermediate formation of γ-lactols, which are also substrates for oxidation with Acetobacter aceti MIM 2000/28, as validated by selective biotransformation of 6β,7β;15β,16β-dimethylene-3-oxo-17α-pregn-4-en-21,17-carbolactol to drospirenone.
Biocatalytic oxidation of 1,4-diols and γ-lactols into γ-lactones : application to chemoenzymatic synthesis of drospirenone / D. Romano, M. Contente, T. Granato, W. Remelli, P. Zambelli, F. Molinari. - In: MONATSHEFTE FÜR CHEMIE. - ISSN 0026-9247. - 144:5(2013 May), pp. 735-737.
Titolo: | Biocatalytic oxidation of 1,4-diols and γ-lactols into γ-lactones : application to chemoenzymatic synthesis of drospirenone |
Autori: | ZAMBELLI, PAOLO (Penultimo) MOLINARI, FRANCESCO ENZO (Corresponding) |
Parole Chiave: | γ-Lactones; acetobacter; drospirenone; enzymatic oxidation |
Settore Scientifico Disciplinare: | Settore CHIM/11 - Chimica e Biotecnologia delle Fermentazioni |
Data di pubblicazione: | mag-2013 |
Rivista: | |
Tipologia: | Article (author) |
Data ahead of print / Data di stampa: | 1-mar-2013 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s00706-012-0921-3 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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