AIMS: To evaluate late toxicity and cosmetic outcome after intraoperative radiotherapy using electrons (ELIOT) as sole treatment modality in early breast cancer patients. METHODS: A total of 119 patients selected randomly among 1200 cases was analyzed. Late toxicities were documented using the LENT-SOMA scoring system, cosmesis was evaluated with the Harvard scale, and a numeric rating scale was used to assess symptoms. RESULTS: After a median follow-up of 71 months, grade II fibrosis was observed in 38 patients (31.9%) and grade III fibrosis in 7 patients (5.9%). Postoperative complications (12.6%) did not correlate with late toxicity. Physicians and patients scored cosmesis as excellent or good in 84% and 77.3% of the cases, respectively. Patient satisfaction was higher than 90%. CONCLUSIONS: In the study, ELIOT gives low and acceptable long-term toxicity. A longer follow-up and a larger number of patients are needed to confirm these promising results.
Long-term side effects and cosmetic outcome in a pool of breast cancer patients treated with intraoperative radiotherapy with electrons as sole treatment / M.C. Leonardi, G.B. Ivaldi, L. Santoro, R. Lazzari, A. Ferrari, A. Morra, P. Caldarella, L. Burgoa, F.D. Bassi, C. Sangalli, N. Rotmensz, A. Luini, U. Veronesi, R. Orecchia. - In: TUMORI. - ISSN 0300-8916. - 98:3(2012 May), pp. 324-330.
|Titolo:||Long-term side effects and cosmetic outcome in a pool of breast cancer patients treated with intraoperative radiotherapy with electrons as sole treatment|
ORECCHIA, ROBERTO (Ultimo)
|Parole Chiave:||beauty ; mastectomy, segmental ; aged ; breast neoplasms ; carcinoma, ductal, breast ; carcinoma, lobular ; electrons ; female ; fibrosis ; follow-up studies ; humans ; intraoperative period ; Italy ; middle aged ; neoplasm grading ; neoplasm staging ; patient satisfaction ; radiotherapy dosage ; radiotherapy, adjuvant ; treatment outcome ; tumor markers, biological|
|Settore Scientifico Disciplinare:||Settore MED/36 - Diagnostica per Immagini e Radioterapia|
|Data di pubblicazione:||mag-2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1700/1125.12400|
|Appare nelle tipologie:||01 - Articolo su periodico|