Noncirrhotic portal hypertension is an uncommon liver disease of unknown origin, increasingly described in HIV-infected adults. Prolonged antiretroviral exposure, in particular to didanosine, and thrombophilic predisposition have been suggested as potential pathogenic factors. Data are limited in children. We describe a 10-year-old HIV-infected girl with noncirrhotic portal hypertension who presented with progressive spleen enlargement and variceal bleeding.
Splenomegaly and variceal bleeding in a 10-year-old HIV-Infected Girl Diagnosed with Noncirrhotic Portal Hypertension / V. Giacomet, A. Viganò, F. Penagini, V. Manfredini, G. Maconi, M. Camozzi, G.V. Zuccotti. - In: THE PEDIATRIC INFECTIOUS DISEASE JOURNAL. - ISSN 0891-3668. - 31:10(2012 Oct), pp. 1059-1060.
Splenomegaly and Variceal Bleeding in a Ten-year-old HIV-infected Girl With Noncirrhotic Portal Hypertension
V. Giacomet;F. Penagini;V. Manfredini;G. Maconi;G.V. Zuccotti
2012
Abstract
Noncirrhotic portal hypertension is an uncommon liver disease of unknown origin, increasingly described in HIV-infected adults. Prolonged antiretroviral exposure, in particular to didanosine, and thrombophilic predisposition have been suggested as potential pathogenic factors. Data are limited in children. We describe a 10-year-old HIV-infected girl with noncirrhotic portal hypertension who presented with progressive spleen enlargement and variceal bleeding.
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