Pressure-volume curves of the lungs and chest wall require knowledge of an effective ‘average’ pleural pressure (Pplav), and are usually estimated using esophageal pressure as PLes-V and PWes-V curves. Such estimates could be misleading when Ppl becomes spatially non-uniform with lung lavage or shape distortion of the chest. We therefore measured PLes-V and PWes-V curves in conditions causing spatial non-uniformity of Ppl in rats. PLes-V curves of normal lungs were unchanged by chest removal. Lung lavage depressed PLes-V but not PWes-V curves to lower volumes, and chest removal after lavage increased volumes at PL≥15 cmH2O by relieving distortion of the mechanically heterogeneous lungs. Chest wall distortion by ribcage compression or abdominal distension depressed PWes-V curves and PLes-V curves of normal lungs only at PL≥3 cmH2O. In conclusion, Pes reflects Pplav with normal and mechanically heterogeneous lungs. With chest wall distortion and dependent deformation of the normal lung, changes of PLes-V curves are qualitatively consistent with greater work of inflation

Esophageal pressure as an estimate of average pleural pressure with lung or chest distortion in rats / M.M. Pecchiari, S.H. Loring, E. D'Angelo. - In: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY. - ISSN 1569-9048. - 186:2(2013 Apr), pp. 229-235. [10.1016/j.resp.2013.02.006]

Esophageal pressure as an estimate of average pleural pressure with lung or chest distortion in rats

M.M. Pecchiari
Primo
;
E. D'Angelo
Ultimo
2013

Abstract

Pressure-volume curves of the lungs and chest wall require knowledge of an effective ‘average’ pleural pressure (Pplav), and are usually estimated using esophageal pressure as PLes-V and PWes-V curves. Such estimates could be misleading when Ppl becomes spatially non-uniform with lung lavage or shape distortion of the chest. We therefore measured PLes-V and PWes-V curves in conditions causing spatial non-uniformity of Ppl in rats. PLes-V curves of normal lungs were unchanged by chest removal. Lung lavage depressed PLes-V but not PWes-V curves to lower volumes, and chest removal after lavage increased volumes at PL≥15 cmH2O by relieving distortion of the mechanically heterogeneous lungs. Chest wall distortion by ribcage compression or abdominal distension depressed PWes-V curves and PLes-V curves of normal lungs only at PL≥3 cmH2O. In conclusion, Pes reflects Pplav with normal and mechanically heterogeneous lungs. With chest wall distortion and dependent deformation of the normal lung, changes of PLes-V curves are qualitatively consistent with greater work of inflation
abdominal distension; chest compression; chest wall mechanics; lung mechanics; rib cage restriction
Settore BIO/09 - Fisiologia
Settore MED/41 - Anestesiologia
apr-2013
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/222581
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