Studies on the Pd-catalyzed hydroarylation reaction of a library of differently substituted norbornene amino acid derivatives with numerous halogenoarenes are described. The effect on the regiochemistry of remote substituents, arylating agents and reaction conditions was considered. The reaction occurred with moderate to good yields and a moderate level of regioselectivity being the coupling at C-5 favorite.

Hydroarylation of substituted norbornene amino acids : studies on long-range stereo-electronic effects on the regioselectivity of the addition / A. Ruffoni, A. Casoni, M.L. Gelmi, S. Pellegrino, F. Clerici. - In: CURRENT ORGANIC CHEMISTRY. - ISSN 1385-2728. - 16:22(2012), pp. 2724-2738. [10.2174/138527212804004472]

Hydroarylation of substituted norbornene amino acids : studies on long-range stereo-electronic effects on the regioselectivity of the addition

A. Ruffoni
Primo
;
A. Casoni
Secondo
;
M.L. Gelmi;S. Pellegrino
Penultimo
;
F. Clerici
Ultimo
2012

Abstract

Studies on the Pd-catalyzed hydroarylation reaction of a library of differently substituted norbornene amino acid derivatives with numerous halogenoarenes are described. The effect on the regiochemistry of remote substituents, arylating agents and reaction conditions was considered. The reaction occurred with moderate to good yields and a moderate level of regioselectivity being the coupling at C-5 favorite.
bicyclic alkenes; catalysis; hydroarylations; norbornene amino acid derivatives; Pd-catalyzed reactions; regioselectivity
Settore CHIM/06 - Chimica Organica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/221216
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