Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone marrow. Currently MSCs may also be isolated from several alternative sources and they have been used in more than a hundred clinical trials worldwide to treat a wide variety of diseases. The MSCs mechanism of action is undefined and currently under investigation. For in vivo purposes MSCs must be produced in compliance with good manufacturing practices and this has stimulated research on MSCs characterization and safety. The objective of this review is to describe recent developments regarding MSCs properties, physiological effects, delivery, clinical applications and possible side effects.

Mesenchymal stem/stromal cells: a new ''cells as drugs'' paradigm : efficacy and critical aspects in cell therapy / L. De Girolamo, E. Lucarelli, G. Alessandri, M.A. Avanzini, M.E. Bernardo, E. Biagi, A.T. Brini, G. D'Amico, F. Fagioli, I. Ferrero, F. Locatelli, R. Maccario, M.Marazzi, O. Parolini, A. Pessina, M.L. Torre. - In: CURRENT PHARMACEUTICAL DESIGN. - ISSN 1381-6128. - 19:13(2013 Apr), pp. 2459-2473. [10.2174/1381612811319130015]

Mesenchymal stem/stromal cells: a new ''cells as drugs'' paradigm : efficacy and critical aspects in cell therapy

L. De Girolamo;A.T. Brini;A. Pessina;
2013-04

Abstract

Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone marrow. Currently MSCs may also be isolated from several alternative sources and they have been used in more than a hundred clinical trials worldwide to treat a wide variety of diseases. The MSCs mechanism of action is undefined and currently under investigation. For in vivo purposes MSCs must be produced in compliance with good manufacturing practices and this has stimulated research on MSCs characterization and safety. The objective of this review is to describe recent developments regarding MSCs properties, physiological effects, delivery, clinical applications and possible side effects.
Advanced therapy medicinal product; Cell therapy; Graft versus host disease; Immunomodulatory properties; Mesenchymal stem/stromal cells; MSCs sources; Regenerative medicine; Transplantation
Settore BIO/14 - Farmacologia
Settore MED/07 - Microbiologia e Microbiologia Clinica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/220941
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