FtsZ is a protein involved in the bacterial division process and is thus an emerging target for antibacterial drugs. The network of interactions between FtsZ monomers necessary for exploitation of its biological function are studied here with molecular dynamics and free energy calculations. The results obtained led to the design of FtsZ targeting peptides which exhibited activity against the function of FtsZ in vitro.

Computer aided design of FtsZ targeting oligopeptides / S. Pieraccini, S. Rendine, C. Jobichen, P. Domadia, J. Sivaraman, P. Francescato, G. Speranza, M. Sironi. - In: RSC ADVANCES. - ISSN 2046-2069. - 3:6(2013), pp. 1739-1743. [10.1039/C2RA21886K]

Computer aided design of FtsZ targeting oligopeptides

S. Pieraccini
Primo
;
S. Rendine
Secondo
;
P. Francescato;G. Speranza
Penultimo
;
M. Sironi
Ultimo
2013

Abstract

FtsZ is a protein involved in the bacterial division process and is thus an emerging target for antibacterial drugs. The network of interactions between FtsZ monomers necessary for exploitation of its biological function are studied here with molecular dynamics and free energy calculations. The results obtained led to the design of FtsZ targeting peptides which exhibited activity against the function of FtsZ in vitro.
Settore CHIM/02 - Chimica Fisica
Settore CHIM/06 - Chimica Organica
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/220733
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 8
social impact