The unprecedented use of ionic liquids in the synthesis of peptide nucleic acids (PNA) oligomers has been investigated. As a proof of concept, the preparation of PNA dimers in ILs has been performed using last generation coupling reagents. More importantly, the application of the supported ionic liquid phase (SILP) technique to the preparation of a PNA dimer has been achieved, including loading, chain elongation and cleavage from the IL support of the PNA fragment.
Ionic liquid mediated synthesis of peptide nucleic acids dimers / L. Poletti, C. Giannini. - In: TETRAHEDRON. - ISSN 0040-4020. - 69:7(2013 Feb 18), pp. 1940-1944. [10.1016/j.tet.2012.12.050]
Ionic liquid mediated synthesis of peptide nucleic acids dimers
L. PolettiPrimo
;C. Giannini
2013
Abstract
The unprecedented use of ionic liquids in the synthesis of peptide nucleic acids (PNA) oligomers has been investigated. As a proof of concept, the preparation of PNA dimers in ILs has been performed using last generation coupling reagents. More importantly, the application of the supported ionic liquid phase (SILP) technique to the preparation of a PNA dimer has been achieved, including loading, chain elongation and cleavage from the IL support of the PNA fragment.
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