The development of a purposely devised mold and a newly set up injection molding (IM) manufacturing process was undertaken to prepare swellable/erodible hydroxypropyl cellulose-based capsular containers. When orally administered, such devices would be intended to achieve pulsatile and/or colonic time-dependent delivery of drugs. An in-depth evaluation of thermal, rheological, and mechanical characteristics of melt formulations/molded items made of the selected polymer (Klucel® LF) with increasing amounts of plasticizer (polyethylene glycol 1500, 5%-15% by weight) was preliminarily carried out. On the basis of the results obtained, a new mold was designed that allowed, through an automatic manufacturing cycle of 5s duration, matching cap and body items to be prepared. These were subsequently filled and coupled to give a closed device of constant 600μm thickness. As compared with previous IM systems having the same composition, such capsules showed improved closure mechanism, technological properties, especially in terms of reproducibility of the shell thickness, and release performance. Moreover, the ability of the capsular container to impart a constant lag phase before the liberation of the contents was demonstrated irrespective of the conveyed formulation.

Injection-Molded Capsular Device for Oral Pulsatile Release: Development of a Novel Mold / L. Zema, G. Loreti, E. Macchi, A. Foppoli, A. Maroni, A. Gazzaniga. - In: JOURNAL OF PHARMACEUTICAL SCIENCES. - ISSN 0022-3549. - 102:2(2013), pp. 489-499.

Injection-Molded Capsular Device for Oral Pulsatile Release: Development of a Novel Mold

L. Zema
Primo
;
G. Loreti
Secondo
;
E. Macchi;A. Foppoli;A. Maroni
Penultimo
;
A. Gazzaniga
Ultimo
2013

Abstract

The development of a purposely devised mold and a newly set up injection molding (IM) manufacturing process was undertaken to prepare swellable/erodible hydroxypropyl cellulose-based capsular containers. When orally administered, such devices would be intended to achieve pulsatile and/or colonic time-dependent delivery of drugs. An in-depth evaluation of thermal, rheological, and mechanical characteristics of melt formulations/molded items made of the selected polymer (Klucel® LF) with increasing amounts of plasticizer (polyethylene glycol 1500, 5%-15% by weight) was preliminarily carried out. On the basis of the results obtained, a new mold was designed that allowed, through an automatic manufacturing cycle of 5s duration, matching cap and body items to be prepared. These were subsequently filled and coupled to give a closed device of constant 600μm thickness. As compared with previous IM systems having the same composition, such capsules showed improved closure mechanism, technological properties, especially in terms of reproducibility of the shell thickness, and release performance. Moreover, the ability of the capsular container to impart a constant lag phase before the liberation of the contents was demonstrated irrespective of the conveyed formulation.
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
2013
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/220204
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