The pathogenesis of vascular damage in Behçet's disease (BD) is still unknown. We investigated anticardiolipin antibodies (AC) in a genetically homogeneous group of Italian patients with BD and retinal vasculitis. In a subset, we examined the level of factor VIII-related antigen and antiendothelial cell antibodies (AECA). We found a high prevalence of AC; AECA were not found in most of our patients. Only three patients had raised levels of factor VIII-related antigen, all of whom had systemic involvement. We believe BD may be considered as a vasculitis of unknown origin in which several and different pathogenetic factors may play a role
Markers of vascular injury in Behçet's disease associated with retinal vasculitis / P. Pivetti-Pezzi, R. Priori, G. Catarinelli, P.L. Meroni, A.B. Federici, M. Abdulaziz, M. Falco, G. Valesini. - In: ANNALS OF OPHTHALMOLOGY. - ISSN 0003-4886. - 24:11(1992 Nov), pp. 411-414.
Markers of vascular injury in Behçet's disease associated with retinal vasculitis
P.L. Meroni;A.B. Federici;
1992
Abstract
The pathogenesis of vascular damage in Behçet's disease (BD) is still unknown. We investigated anticardiolipin antibodies (AC) in a genetically homogeneous group of Italian patients with BD and retinal vasculitis. In a subset, we examined the level of factor VIII-related antigen and antiendothelial cell antibodies (AECA). We found a high prevalence of AC; AECA were not found in most of our patients. Only three patients had raised levels of factor VIII-related antigen, all of whom had systemic involvement. We believe BD may be considered as a vasculitis of unknown origin in which several and different pathogenetic factors may play a rolePubblicazioni consigliate
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