The effect of loperamide and naloxone on mouth-to-caecum transit time was evaluated by the lactulose hydrogen breath test in four men and four women. Each subject underwent tests during the administration of placebo, loperamide (12-16 mg po), naloxone (40 micrograms/kg/h by a three-hour intravenous infusion), and loperamide plus naloxone, carried out at intervals of one or two weeks. The transit time was significantly longer after loperamide, and this effect was antagonised by the concomitant administration of naloxone whereas naloxone administered alone had no effect on mean transit time. No clinically important side effects were reported.

Effect of loperamide and naloxone on mounth-to-caecum transit time evaluated by lactulose hydrogen breath test / G. Basilisco, A. Bozzani, G. Camboni, M. Recchia, M. Quatrini, D. Conte, R. Penagini, PA Bianchi. - In: GUT. - ISSN 0017-5749. - 26:7(1985), pp. 700-703.

Effect of loperamide and naloxone on mounth-to-caecum transit time evaluated by lactulose hydrogen breath test

D. Conte;R. Penagini
Penultimo
;
1985

Abstract

The effect of loperamide and naloxone on mouth-to-caecum transit time was evaluated by the lactulose hydrogen breath test in four men and four women. Each subject underwent tests during the administration of placebo, loperamide (12-16 mg po), naloxone (40 micrograms/kg/h by a three-hour intravenous infusion), and loperamide plus naloxone, carried out at intervals of one or two weeks. The transit time was significantly longer after loperamide, and this effect was antagonised by the concomitant administration of naloxone whereas naloxone administered alone had no effect on mean transit time. No clinically important side effects were reported.
Settore MED/12 - Gastroenterologia
1985
GUT
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/213016
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