Several xenobiotics undergo biotransformation reactions which yield reactive and potentially toxic compounds. Activation may occur via cytochrome P-450-mediated oxidation, prostaglandin synthetase-related hydroperoxidase-activity, or alcohol dehydrogenase/aldehyde dehydrogenase activity. The reactive metabolites thus formed may initiate lipid peroxidation or covalent binding to cell macromolecules, and secondarily lead to acute cytotoxicity or to tumorigenesis. Most cells possess mechanisms for protection against chemical toxicity, e.g. glutathione-related pathways and epoxide hydrolase activity. A possible strategy in handling toxic drug effects in the clinical situation may be chemotherapeutic manipulations aiming at a stimulation of protective mechanisms or at an inhibition of activating pathways.

Ceftezole levels in serum, bronchial secretun and pulmonary tissue / F. FRASCHINI, F. SCAGLIONE, F. VAROLI, G.C. ROVIARO, M. FALCHI, F. FERRARA. - In: CHEMIOTERAPIA. - ISSN 0392-906X. - 4:Suppl. al n. 2(1985 Apr), pp. 343-344. ((Intervento presentato al 4. convegno Mediterranean Congress of Chemotherapy tenutosi a Rhodos, Greece nel 1984.

Ceftezole levels in serum, bronchial secretun and pulmonary tissue

F. FRASCHINI;F. SCAGLIONE;F. VAROLI;G.C. ROVIARO;
1985-04

Abstract

Several xenobiotics undergo biotransformation reactions which yield reactive and potentially toxic compounds. Activation may occur via cytochrome P-450-mediated oxidation, prostaglandin synthetase-related hydroperoxidase-activity, or alcohol dehydrogenase/aldehyde dehydrogenase activity. The reactive metabolites thus formed may initiate lipid peroxidation or covalent binding to cell macromolecules, and secondarily lead to acute cytotoxicity or to tumorigenesis. Most cells possess mechanisms for protection against chemical toxicity, e.g. glutathione-related pathways and epoxide hydrolase activity. A possible strategy in handling toxic drug effects in the clinical situation may be chemotherapeutic manipulations aiming at a stimulation of protective mechanisms or at an inhibition of activating pathways.
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/211278
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