n-3 Fatty acids may reduce the incidence of sudden cardiac death, a property potentially related to their activity on myocardial excitability. We carried out a cross-over trial in which 10 coronary patients were treated with n-3 ethyl esters at two different dosages (3 and 6 g day (-1)) for 4 weeks. Plasma fatty acid composition, lipid profile, and heart rate variability (HRV) were analysed. n-3 Fatty acid intake significantly reduced plasma cholesterol and triglyceride levels and decreased the low to high frequency ratio. In addition, significant positive correlations were found between n-3 phospholipid content and HRV indices, thus confirming, in a prospective trial, retrospective data suggesting that an increased HRV may be achieved in coronary patients by exogenous provision of n-3 fatty acids.
|Titolo:||Omega-3 fatty acid ethyl esters increase heart rate variability in patients with coronary disease|
|Parole Chiave:||Coronary disease; Fatty acids; Heart rate variability; Plasma lipids|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||giu-2002|
|Digital Object Identifier (DOI):||10.1006/phrs.2002.0989|
|Appare nelle tipologie:||01 - Articolo su periodico|