n-3 Fatty acids may reduce the incidence of sudden cardiac death, a property potentially related to their activity on myocardial excitability. We carried out a cross-over trial in which 10 coronary patients were treated with n-3 ethyl esters at two different dosages (3 and 6 g day (-1)) for 4 weeks. Plasma fatty acid composition, lipid profile, and heart rate variability (HRV) were analysed. n-3 Fatty acid intake significantly reduced plasma cholesterol and triglyceride levels and decreased the low to high frequency ratio. In addition, significant positive correlations were found between n-3 phospholipid content and HRV indices, thus confirming, in a prospective trial, retrospective data suggesting that an increased HRV may be achieved in coronary patients by exogenous provision of n-3 fatty acids.
Omega-3 fatty acid ethyl esters increase heart rate variability in patients with coronary disease / B. Villa, L. Calabresi, G. Chiesa, P. Risè, C. Galli, C.R. Sirtori. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - 45:6(2002 Jun), pp. 475-478.
Omega-3 fatty acid ethyl esters increase heart rate variability in patients with coronary disease
L. Calabresi;G. Chiesa;P. Risè;C. Galli;C.R. Sirtori
2002
Abstract
n-3 Fatty acids may reduce the incidence of sudden cardiac death, a property potentially related to their activity on myocardial excitability. We carried out a cross-over trial in which 10 coronary patients were treated with n-3 ethyl esters at two different dosages (3 and 6 g day (-1)) for 4 weeks. Plasma fatty acid composition, lipid profile, and heart rate variability (HRV) were analysed. n-3 Fatty acid intake significantly reduced plasma cholesterol and triglyceride levels and decreased the low to high frequency ratio. In addition, significant positive correlations were found between n-3 phospholipid content and HRV indices, thus confirming, in a prospective trial, retrospective data suggesting that an increased HRV may be achieved in coronary patients by exogenous provision of n-3 fatty acids.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.