Arterial windkessel mechanisms and arterial pressure (AP) low frequency (LF) waves were investigated by means of simple lumped models of a compliant resistant/arterial tree and of flow regulation in peripheral vascular districts (PVDs) with three types of feedback: J) delay, 2) Van der Pol oscillator, 3) relay; all were able to actively compensate flow changes and to simulate peripheral LF vasomotion. Each PVD connected to a Windkessel compartment displayed a reduction and a disappearance of oscillations with low compliance, when the Windkessel equivalent time constant T/sub eq/ fall below 2s. Two PVDs connected to the same Windkessel tended to phase opposition with a negative interference canceling their LF oscillations from AP. With a modest neural drive, cancellation was imperfect and AP waves appeared. Vasomotion, arterial compliances and neural triggers are all essential informing LF AP variability.
|Titolo:||Modeling the role of arterial windkessel in the enhancement and synchronization of low frequency vasomotor activity|
PORTA, ALBERTO (Secondo)
PAGANI, MASSIMO (Ultimo)
|Settore Scientifico Disciplinare:||Settore ING-INF/06 - Bioingegneria Elettronica e Informatica|
Settore MED/09 - Medicina Interna
|Data di pubblicazione:||2003|
|Appare nelle tipologie:||01 - Articolo su periodico|