Notch receptors are transmembrane proteins critically determining cell fate and maintenance of progenitor cells in many developmental systems. Notch signaling is involved in stem cell self-renewal and regulates the main functions of cell life at different levels of development: cell proliferation, differentiation and apoptosis. By virtue of its involvement in the regulation of cell physiology, it is not surprising that a deregulation of the Notch pathway leads to the development of different tumors. In this review, we critically discuss the latest findings concerning Notch roles in hematologic oncology, with a special focus on T-cell acute lymphoblastic leukemia and B-cell malignancies. We also describe the molecular mediators of Notch-driven oncogenic effects and the current pharmacological approaches targeting Notch signaling.
Notch-ing from T-cell to B-cell limphoid malignancies / L. Mirandola, P. Comi, E. Cobos, W.M. Kast, M. Chiriva-Internati, R. Chiaramonte. - In: CANCER LETTERS. - ISSN 0304-3835. - 308:1(2011 Sep 01), pp. 1-13.
Notch-ing from T-cell to B-cell limphoid malignancies
L. MirandolaPrimo
;P. ComiSecondo
;R. ChiaramonteUltimo
2011
Abstract
Notch receptors are transmembrane proteins critically determining cell fate and maintenance of progenitor cells in many developmental systems. Notch signaling is involved in stem cell self-renewal and regulates the main functions of cell life at different levels of development: cell proliferation, differentiation and apoptosis. By virtue of its involvement in the regulation of cell physiology, it is not surprising that a deregulation of the Notch pathway leads to the development of different tumors. In this review, we critically discuss the latest findings concerning Notch roles in hematologic oncology, with a special focus on T-cell acute lymphoblastic leukemia and B-cell malignancies. We also describe the molecular mediators of Notch-driven oncogenic effects and the current pharmacological approaches targeting Notch signaling.File | Dimensione | Formato | |
---|---|---|---|
Mirandola. Cancer Letters.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
219.89 kB
Formato
Adobe PDF
|
219.89 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.