Peripheral nerves are subject to the same types of problems as other tissues: inflammation, toxicity, swelling, permeability, leading to neuropathies. Nutrients offer an alternative for people who want to avoid the side effects of prescription drugs. These studies were designed to assess the pharmacodynamic interaction between alpha-lipoic acid (ALA) and docosahexaenoic acid (DHA) in controlling the inflammatory response induced by carrageenan in the rat. Particularly, the activity of ALA (100 mg/kg per os) and DHA (200 mg/kg per os), given alone or in combination, was evaluated by paw oedema method. The results of the present study clearly indicate that the new formulation containing ALA plus DHA, in a range of 2:1, had significantly greater effect than either DHA or ALA alone in antagonizing carrageenan-induced inflammatory response. These results indicate that ALA plus DHA induce a favourable pharmacodynamic interaction which can be considered to be synergistic, at least in these experimental settings
Alpha-lipoic acid and docosahexaenoic acid: a positive interaction on the carrageenan inflammatory response in rats / G. Rossoni, B.M. Stankov. - In: NUTRAFOODS. - ISSN 1827-8590. - 9:3(2010), pp. 21-25.
Titolo: | Alpha-lipoic acid and docosahexaenoic acid: a positive interaction on the carrageenan inflammatory response in rats |
Autori: | ROSSONI, GIUSEPPE BATTISTA (Primo) |
Parole Chiave: | alpha-lipoic acid ; docosahexaenoic acid ; inflammation ; carrageenan ; neuropathy |
Settore Scientifico Disciplinare: | Settore BIO/14 - Farmacologia |
Data di pubblicazione: | 2010 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/BF03223338 |
Appare nelle tipologie: | 01 - Articolo su periodico |