The goal of this study was to investigate whether the janus kinase/signal transducer and activator of transcription (JAK/STAT) signal transduction pathway is present and active in meningiomas. The results of these investigations are important for all meningioma therapies that, similar to interferon-alpha-2B (IFNalpha-2B), depend on activation of this pathway for their effect. The authors were interested in evaluating the importance, if any, of the JAK/STAT pathway in the biology and therapy for these tumors.
Expression of the JAK and STAT superfamilies in human meningiomas / L. Magrassi, C. De-Fraja, L. Conti, G. Butti, L. Infuso, S. Govoni, E. Cattaneo. - In: JOURNAL OF NEUROSURGERY. - ISSN 0022-3085. - 91:3(1999 Sep 03), pp. 440-446. [10.3171/jns.1999.91.3.0440]
Expression of the JAK and STAT superfamilies in human meningiomas
L. Conti;E. CattaneoUltimo
1999
Abstract
The goal of this study was to investigate whether the janus kinase/signal transducer and activator of transcription (JAK/STAT) signal transduction pathway is present and active in meningiomas. The results of these investigations are important for all meningioma therapies that, similar to interferon-alpha-2B (IFNalpha-2B), depend on activation of this pathway for their effect. The authors were interested in evaluating the importance, if any, of the JAK/STAT pathway in the biology and therapy for these tumors.
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