The goal of this study was to investigate whether the janus kinase/signal transducer and activator of transcription (JAK/STAT) signal transduction pathway is present and active in meningiomas. The results of these investigations are important for all meningioma therapies that, similar to interferon-alpha-2B (IFNalpha-2B), depend on activation of this pathway for their effect. The authors were interested in evaluating the importance, if any, of the JAK/STAT pathway in the biology and therapy for these tumors.

Expression of the JAK and STAT superfamilies in human meningiomas / L. Magrassi, C. De-Fraja, L. Conti, G. Butti, L. Infuso, S. Govoni, E. Cattaneo. - In: JOURNAL OF NEUROSURGERY. - ISSN 0022-3085. - 91:3(1999 Sep 03), pp. 440-446. [10.3171/jns.1999.91.3.0440]

Expression of the JAK and STAT superfamilies in human meningiomas

L. Conti;E. Cattaneo
Ultimo
1999-09-03

Abstract

The goal of this study was to investigate whether the janus kinase/signal transducer and activator of transcription (JAK/STAT) signal transduction pathway is present and active in meningiomas. The results of these investigations are important for all meningioma therapies that, similar to interferon-alpha-2B (IFNalpha-2B), depend on activation of this pathway for their effect. The authors were interested in evaluating the importance, if any, of the JAK/STAT pathway in the biology and therapy for these tumors.
Meningeal Neoplasms ; Janus Kinase 1 ; Janus Kinase 3 ; Antineoplastic Agents ; Humans ; STAT3 Transcription Factor ; Aged ; Gene Expression Regulation, Neoplastic ; Tumor Cells, Cultured ; Phosphorylation ; TYK2 Kinase ; Meningioma ; Trans-Activators ; Male; Signal Transduction; Interferon-alpha ; Recombinant Proteins ; DNA-Binding Proteins ; Protein-Tyrosine Kinases ; Cell Nucleus ; Transcriptional Activation ; Blotting, Western ; Neoplasm Proteins ; STAT1 Transcription Factor ; Dura Mater ; Acute-Phase Proteins ; Proteins ; Middle Aged ; Female
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/206898
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