We report a new chromosomal reciprocal translocation t(5;10)(q33;q22) in a 49-year-old man with atypical chronic myeloid leukemia (a-CML) and history of occupational exposure to petroleum products including benzene and other hydrocarbons. The t(5;10) (q33;q22) was found in 94% and 84% of metaphases in peripheral blood and bone marrow cells, respectively. Cytogenetic analysis of single colonies derived from granulocyte-macrophage (CFU-GM), and erythroid (BFU-E) hematopoietic progenitors showed that 88% and 40% of CFU-GM and BFU-E, respectively, had the t(5;10)(q33;q22). In contrast, peripheral blood T-lymphocytes, and cutaneous fibroblasts had normal 46,XY karyotype. Molecular analysis of the t(5;10)(q33;q22) translocation breakpoint is currently underway in order to identify genes located in this region which might provide insights into the pathogenesis of atypical myeloproliferative disorders.

New reciprocal translocation t(5;10)(q33;q22) associated with atypical chronic myeloid leukemia / S. Siena, G. Sammarelli, M.G. Grimoldi, R. Schiavo, A. Nozza, M. Roncalli, C. Mecucci, A. Santoro, C. Carlo-Stella. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 84:4(1999 Apr), pp. 369-372.

New reciprocal translocation t(5;10)(q33;q22) associated with atypical chronic myeloid leukemia

S. Siena;M.G. Grimoldi;M. Roncalli;C. Carlo-Stella
1999-04

Abstract

We report a new chromosomal reciprocal translocation t(5;10)(q33;q22) in a 49-year-old man with atypical chronic myeloid leukemia (a-CML) and history of occupational exposure to petroleum products including benzene and other hydrocarbons. The t(5;10) (q33;q22) was found in 94% and 84% of metaphases in peripheral blood and bone marrow cells, respectively. Cytogenetic analysis of single colonies derived from granulocyte-macrophage (CFU-GM), and erythroid (BFU-E) hematopoietic progenitors showed that 88% and 40% of CFU-GM and BFU-E, respectively, had the t(5;10)(q33;q22). In contrast, peripheral blood T-lymphocytes, and cutaneous fibroblasts had normal 46,XY karyotype. Molecular analysis of the t(5;10)(q33;q22) translocation breakpoint is currently underway in order to identify genes located in this region which might provide insights into the pathogenesis of atypical myeloproliferative disorders.
chromosomal translocation t(5;10)(q33;q22) ; atypical chronic myeloid leukemia
Settore MED/08 - Anatomia Patologica
http://www.haematologica.org/content/84/4/369.long
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/206417
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