A 44-year-old man developed a peripheral neuropathy during treatment with interferon-alpha for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biopsy confirmed primary axonal damage. Immunofluorescence studies showed increased expression of HLA-DR molecules prevalently on Schwann cells of non-myelin-forming type.
Axonal neuropathy associated with interferon-alpha treatment for hepatitis C : HLA-DR immunoreactivity in Schwann cells / A. Quattrini, G. Comi, R. Nemni, V. Martinelli, A. Villa, M. Caimi, L. Wrabetz, N. Canal. - In: ACTA NEUROPATHOLOGICA. - ISSN 0001-6322. - 94:5(1997 Nov), pp. 504-508. [10.1007/s004010050740]
Axonal neuropathy associated with interferon-alpha treatment for hepatitis C : HLA-DR immunoreactivity in Schwann cells
G. ComiSecondo
;R. Nemni;N. CanalUltimo
1997
Abstract
A 44-year-old man developed a peripheral neuropathy during treatment with interferon-alpha for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biopsy confirmed primary axonal damage. Immunofluorescence studies showed increased expression of HLA-DR molecules prevalently on Schwann cells of non-myelin-forming type.
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