We defined a sub-family of zinc finger proteins by computer analyses and comparisons of five new finger domains against protein databases. This subclass of the cysteine-cysteine/histidine-histidine motif shows additional well conserved amino acid patterns and belongs to the human kox and gli-Kruppel gene family, sharing also the same stretches of regulatory zinc finger-containing proteins of mouse and Xenopus. We particularly describe ZF6 cDNA which contains the most interesting sequence, encoding a putative multi-domain regulatory protein.
Computer sequence analysis of highly conserved zinc fingers modules / D. Petroni, E. Bartolini, R. Chiaramonte, S. Ottolenghi, P. Comi. - In: DNA SEQUENCE. - ISSN 1042-5179. - 9:3(1998), pp. 163-169.
Computer sequence analysis of highly conserved zinc fingers modules
R. Chiaramonte;P. ComiUltimo
1998
Abstract
We defined a sub-family of zinc finger proteins by computer analyses and comparisons of five new finger domains against protein databases. This subclass of the cysteine-cysteine/histidine-histidine motif shows additional well conserved amino acid patterns and belongs to the human kox and gli-Kruppel gene family, sharing also the same stretches of regulatory zinc finger-containing proteins of mouse and Xenopus. We particularly describe ZF6 cDNA which contains the most interesting sequence, encoding a putative multi-domain regulatory protein.Pubblicazioni consigliate
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