Docetaxel has been implicated as a causative agent in peripheral neuropathy, but pathological changes in peripheral nerve have not been described. During docetaxel treatment a 54-year-old man developed a sensorimotor polyneuropathy when the overall docetaxel dosage was 540 mg/m(2). Neurophysiological investigation revealed a sensorimotor axonal neuropathy. Fascicular sural nerve biopsy showed an axonal neuropathy with a preferentially loss of large myelinated fibers. There was evidence of considerable fiber regeneration. Sensory and motor symptoms progressively improved after docetaxel withdrawal.

Docetaxel neuropathy: a distal axonopathy / R. Fazio, A. Quattrini, A. Bolognesi, G. Bordogna, E. Villa, S. Previtali, N. Canal, R. Nemni. - In: ACTA NEUROPATHOLOGICA. - ISSN 0001-6322. - 98:6(1999 Dec), pp. 651-653.

Docetaxel neuropathy: a distal axonopathy

R. Nemni
1999

Abstract

Docetaxel has been implicated as a causative agent in peripheral neuropathy, but pathological changes in peripheral nerve have not been described. During docetaxel treatment a 54-year-old man developed a sensorimotor polyneuropathy when the overall docetaxel dosage was 540 mg/m(2). Neurophysiological investigation revealed a sensorimotor axonal neuropathy. Fascicular sural nerve biopsy showed an axonal neuropathy with a preferentially loss of large myelinated fibers. There was evidence of considerable fiber regeneration. Sensory and motor symptoms progressively improved after docetaxel withdrawal.
Docetaxel; Neuropathy; Neurotoxicity; Paclitaxel; Peripheral nerves
Settore MED/26 - Neurologia
Settore MED/08 - Anatomia Patologica
dic-1999
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/203623
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 39
  • ???jsp.display-item.citation.isi??? ND
social impact