BACKGROUND: The T allele of rs9657904 within the CBLB gene was recently found to be significantly associated with multiple sclerosis (MS) in a genome-wide association study in Sardinia. OBJECTIVE: To replicate this association in an independent population with a different genetic background. METHODS: The rs9657904 variant was typed in a sample of 1435 cases and 1466 controls from the Italian mainland. RESULTS: It was found that in this sample also, the common allele T of rs9657904 is significantly positively associated (one-tailed p=7.35 × 10(-5)) and with a comparable effect size with MS (OR=1.31, 95% CI 1.14 to 1.52). CONCLUSION: These data provide further evidence of the association of MS disease with variation within CBLB.
Association of the CBLB gene with multiple sclerosis: new evidence from a replication study in an Italian population / L. Corrado, L. Bergamaschi, N. Barizzone, M.E. Fasano, F.R. Guerini, M. Salvetti, D. Galimberti, M.D. Benedetti, M. Leone, S. D'Alfonso. - In: JOURNAL OF MEDICAL GENETICS. - ISSN 0022-2593. - 48:3(2011), pp. 210-211.
Association of the CBLB gene with multiple sclerosis: new evidence from a replication study in an Italian population
D. Galimberti;
2011
Abstract
BACKGROUND: The T allele of rs9657904 within the CBLB gene was recently found to be significantly associated with multiple sclerosis (MS) in a genome-wide association study in Sardinia. OBJECTIVE: To replicate this association in an independent population with a different genetic background. METHODS: The rs9657904 variant was typed in a sample of 1435 cases and 1466 controls from the Italian mainland. RESULTS: It was found that in this sample also, the common allele T of rs9657904 is significantly positively associated (one-tailed p=7.35 × 10(-5)) and with a comparable effect size with MS (OR=1.31, 95% CI 1.14 to 1.52). CONCLUSION: These data provide further evidence of the association of MS disease with variation within CBLB.File | Dimensione | Formato | |
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