BACKGROUND: The T allele of rs9657904 within the CBLB gene was recently found to be significantly associated with multiple sclerosis (MS) in a genome-wide association study in Sardinia. OBJECTIVE: To replicate this association in an independent population with a different genetic background. METHODS: The rs9657904 variant was typed in a sample of 1435 cases and 1466 controls from the Italian mainland. RESULTS: It was found that in this sample also, the common allele T of rs9657904 is significantly positively associated (one-tailed p=7.35 × 10(-5)) and with a comparable effect size with MS (OR=1.31, 95% CI 1.14 to 1.52). CONCLUSION: These data provide further evidence of the association of MS disease with variation within CBLB.
|Titolo:||Association of the CBLB gene with multiple sclerosis: new evidence from a replication study in an Italian population|
|Parole Chiave:||genome-wide association; susceptibility loci; epidemiology; Europe|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
|Data di pubblicazione:||2011|
|Digital Object Identifier (DOI):||10.1136/jmg.2010.081380|
|Appare nelle tipologie:||01 - Articolo su periodico|