Fully convulsant doses of pentamethylenetetrazole cause marked increase in rat brain cortical PGF2alpha, PGE2, cGMP and cAMP during seizures, whereas subconvulsant doses cause an increase of rat brain cortical PGF2alpha without affecting the other biochemical parameters considered. Rat cerebellar prostaglandins were not modified by the convulsant agent at either dosage.

Relations between prostaglandin E2, F2alpha, and cyclic nucleotides levels in rat brain and induction of convulsions / G. C. Folco, D. Longiave, E. Bosisio. - In: PROSTAGLANDINS. - ISSN 0090-6980. - 13:5(1977 May), pp. 893-900.

Relations between prostaglandin E2, F2alpha, and cyclic nucleotides levels in rat brain and induction of convulsions

G. C. Folco;E. Bosisio
Ultimo
1977

Abstract

Fully convulsant doses of pentamethylenetetrazole cause marked increase in rat brain cortical PGF2alpha, PGE2, cGMP and cAMP during seizures, whereas subconvulsant doses cause an increase of rat brain cortical PGF2alpha without affecting the other biochemical parameters considered. Rat cerebellar prostaglandins were not modified by the convulsant agent at either dosage.
Animals; Dose-Response Relationship, Drug; Brain Chemistry; Cyclic AMP; Brain; Azoles; Cerebral Cortex; Cyclic GMP; Rats; Tetrazoles; Prostaglandins F; Prostaglandins E; Male
Settore BIO/14 - Farmacologia
mag-1977
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/202341
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