OBJECTIVE: Homocysteine is a sex-related risk factor for cardiovascular disease but the reason for dimorphism is unclear. It has been hypothesized that fat-free mass is an independent determinant of the circulating homocysteine and methionine concentrations. METHODS: The relationship of homocysteine to body composition was investigated in 52 healthy middle-aged 40-60year olds. Plasma total homocysteine, methionine, folates, vitamins B6 and B12 concentrations were measured with fat mass, bone mineral content, lean body mass, fat-free mass, body water compartments and resting energy expenditure by Anthropometry, Dual X-ray Absorptiometry, Bioimpedentiometry and Indirect Calorimetry. RESULTS: Men had higher homocysteine (+28%) and methionine (+18%) concentrations than women, but a similar ratio between the two concentrations. Men also had higher lean body mass and fat-free mass. Homocysteine and methionine concentrations were significantly related to fat-free mass, lean body mass, total, extracellular and intracellular water both in simple correlations and in multivariate models including age, smoking habits and vitamin concentrations. Fat-free mass related measures explained the sex effect on homocysteine and methionine concentrations but not the ratio of homocysteine to methionine concentrations. CONCLUSION: In healthy middle-aged adults homocysteine concentration independently relates to fat-free mass and to water components. Homocysteine and methionine concentrations increase together in relation to the proportion of fat-free mass but their ratio is unrelated to fat-free mass.
Body composition: an important determinant of homocysteine and methionine concentrations in healthy individuals / A. Battezzati, S. Bertoli, A. San Romerio, G. Testolin. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - 17:7(2007 Sep), pp. 525-534.
|Titolo:||Body composition: an important determinant of homocysteine and methionine concentrations in healthy individuals|
BATTEZZATI, ALBERTO (Primo)
BERTOLI, SIMONA (Secondo)
SAN ROMERIO, ANTONELLA (Penultimo)
TESTOLIN, GIULIO (Ultimo)
|Parole Chiave:||body composition; folates; homocysteine; lean body mass; methionine|
|Settore Scientifico Disciplinare:||Settore BIO/09 - Fisiologia|
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
|Data di pubblicazione:||set-2007|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.numecd.2006.03.006|
|Appare nelle tipologie:||01 - Articolo su periodico|