Title compds. (I; R = Cl, Br, CF3; n = 0-3; when R = Cl and n = 1-3, then the H atoms at the 1 and 9a positions of the quinolizidinyl ring are trans), were prepd. Thus, 4,7-dichloroquinoline and 1-quinolizidinylamine were refluxed with PhOH for 4 h at 180 to give a separable mixt. of cis, trans-4-(1-quinolizidinylamino)-7-chloroquinoline. The latter showed 6-8 times the antimalarial activity of chloroquine against W2 P. falciparum.

4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity / A. Sparatore, D. Taramelli, N. Basilico, S. Parapini, F. Sparatore, V. Boido, C. Canu Boido.

4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity

A. Sparatore;D. Taramelli;N. Basilico;S. Parapini;
2005-04-28

Abstract

Title compds. (I; R = Cl, Br, CF3; n = 0-3; when R = Cl and n = 1-3, then the H atoms at the 1 and 9a positions of the quinolizidinyl ring are trans), were prepd. Thus, 4,7-dichloroquinoline and 1-quinolizidinylamine were refluxed with PhOH for 4 h at 180 to give a separable mixt. of cis, trans-4-(1-quinolizidinylamino)-7-chloroquinoline. The latter showed 6-8 times the antimalarial activity of chloroquine against W2 P. falciparum.
Universita' Degli Studi Di Milano
WO2005/037833
PCT/IB2004/003393
malaria; quinolizidinyl derivatives; chloroquine;
Settore CHIM/08 - Chimica Farmaceutica
4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity / A. Sparatore, D. Taramelli, N. Basilico, S. Parapini, F. Sparatore, V. Boido, C. Canu Boido.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/200143
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 54
  • ???jsp.display-item.citation.isi??? 53
social impact