Eukaryotic cells use endocytosis to internalise plasma membrane, surface receptors and their ligands, viruses and various extracellular soluble molecules. Endocytosis has been regarded as a long-term mechanism of signal attenuation via receptor clearance from the cell surface. However, additional, and quite unexpected, functions for endocytosis have emerged, which, together with its attenuation function, project a central role for this process in cellular homeostasis and control of proliferation. Subversion of endocytic control is thus predicted to play a causative role in hyperproliferative conditions, first and foremost cancer.

Endocytosis and cancer / S. Polo, S. Pece, P.P. Di Fiore. - In: CURRENT OPINION IN CELL BIOLOGY. - ISSN 0955-0674. - 16:2(2004 Apr), pp. 156-161.

Endocytosis and cancer

S. Polo
Primo
;
S. Pece
Secondo
;
P.P. Di Fiore
Ultimo
2004-04

Abstract

Eukaryotic cells use endocytosis to internalise plasma membrane, surface receptors and their ligands, viruses and various extracellular soluble molecules. Endocytosis has been regarded as a long-term mechanism of signal attenuation via receptor clearance from the cell surface. However, additional, and quite unexpected, functions for endocytosis have emerged, which, together with its attenuation function, project a central role for this process in cellular homeostasis and control of proliferation. Subversion of endocytic control is thus predicted to play a causative role in hyperproliferative conditions, first and foremost cancer.
EGFR; epithelial growth factor receptor; N ecd ; Notch extracellular domain; receptor tyrosine kinase; RTK; sensory organ precursor; SOP
Settore MED/04 - Patologia Generale
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/200043
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