We analysed the 12-week virological response to protease inhibitor (PI) or non-nucleoside reverse transcriptase inhibitor (NNRTI) therapy in 1108 patients carrying B or non-B human immunodeficiency virus (HIV)-1 subtypes with matched resistance mutation patterns. Response rates were not significantly different for non-B and B subtypes stratified for treatment status (51.5% vs. 41.5% in naive patients; 46.7% vs. 38.7% in experienced patients) or regimens (46.9% vs. 39.7% with PI; 56.7% vs. 40% with NNRTI). No difference in response was detected in patients harbouring B and non-B subtypes with any resistance profile. Further studies are advisable to fully test this approach on larger datasets.
Human immunodeficiency virus-1 B and non-B subtypes with the same drug resistance pattern respond similarly to antiretroviral therapy / M. Franzetti, M. Violin, G. Casazza, G. Meini, A. Callegaro, P. Corsi, F. Maggiolo, A.R. Pignataro, S. Paolucci, N. Gianotti, D. Francisci, R. Rossotti, G. Filice, T. Carli, M. Zazzi, C. Balotta. - In: CLINICAL MICROBIOLOGY AND INFECTION. - ISSN 1198-743X. - 18:3(2012 Mar), pp. e66-e70.
Titolo: | Human immunodeficiency virus-1 B and non-B subtypes with the same drug resistance pattern respond similarly to antiretroviral therapy |
Autori: | FRANZETTI, MARCO (Primo) BALOTTA, CLAUDIA (Ultimo) |
Parole Chiave: | Antiretroviral treatment; Drug resistance; HIV-1; HIV-1 evolution; Non-B subtypes |
Settore Scientifico Disciplinare: | Settore MED/17 - Malattie Infettive |
Data di pubblicazione: | mar-2012 |
Rivista: | |
Sostituisce: | http://hdl.handle.net/2434/199137 |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/j.1469-0691.2011.03740.x |
Appare nelle tipologie: | 01 - Articolo su periodico |