We analysed the 12-week virological response to protease inhibitor (PI) or non-nucleoside reverse transcriptase inhibitor (NNRTI) therapy in 1108 patients carrying B or non-B human immunodeficiency virus (HIV)-1 subtypes with matched resistance mutation patterns. Response rates were not significantly different for non-B and B subtypes stratified for treatment status (51.5% vs. 41.5% in naive patients; 46.7% vs. 38.7% in experienced patients) or regimens (46.9% vs. 39.7% with PI; 56.7% vs. 40% with NNRTI). No difference in response was detected in patients harbouring B and non-B subtypes with any resistance profile. Further studies are advisable to fully test this approach on larger datasets.

Human immunodeficiency virus-1 B and non-B subtypes with the same drug resistance pattern respond similarly to antiretroviral therapy / M. Franzetti, M. Violin, G. Casazza, G. Meini, A. Callegaro, P. Corsi, F. Maggiolo, A.R. Pignataro, S. Paolucci, N. Gianotti, D. Francisci, R. Rossotti, G. Filice, T. Carli, M. Zazzi, C. Balotta. - In: CLINICAL MICROBIOLOGY AND INFECTION. - ISSN 1198-743X. - 18:3(2012 Mar), pp. e66-e70.

Human immunodeficiency virus-1 B and non-B subtypes with the same drug resistance pattern respond similarly to antiretroviral therapy

M. Franzetti;G. Casazza;C. Balotta
2012-03

Abstract

We analysed the 12-week virological response to protease inhibitor (PI) or non-nucleoside reverse transcriptase inhibitor (NNRTI) therapy in 1108 patients carrying B or non-B human immunodeficiency virus (HIV)-1 subtypes with matched resistance mutation patterns. Response rates were not significantly different for non-B and B subtypes stratified for treatment status (51.5% vs. 41.5% in naive patients; 46.7% vs. 38.7% in experienced patients) or regimens (46.9% vs. 39.7% with PI; 56.7% vs. 40% with NNRTI). No difference in response was detected in patients harbouring B and non-B subtypes with any resistance profile. Further studies are advisable to fully test this approach on larger datasets.
Antiretroviral treatment; Drug resistance; HIV-1; HIV-1 evolution; Non-B subtypes
Settore MED/17 - Malattie Infettive
http://hdl.handle.net/2434/199137
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/199137
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