In haemodialysis patients, increased concentrations of malonyldialdehyde and decreased vitamin E content indicate lipid peroxidation in the platelets from oxidative damage. The same process has been described in red blood cells and in mononuclear cells in peripheral blood. However, platelet aggregation is within normal limits and does not change after treatment with vitamin E. On the other hand vitamin E supplementation reverts completely the biochemical abnormality of the platelets.
Platelet lipid peroxidation in haemodyalisis patients: effects of vitamin E supplementation / M. Taccone-Gallucci, R. Lubrano, D. Del Principe, A. Menichelli, M. Giordani, G. Citti, M. Morosetti, C. Meloni, V. Mazzarella, L. Meschini, C. Tozzo, M. Elli, O. Giardini, C.U. Casciani. - In: NEPHROLOGY DIALYSIS TRANSPLANTATION. - ISSN 0931-0509. - 4:11(1989), pp. 975-978. [10.1093/oxfordjournals.ndt.a091813]
Platelet lipid peroxidation in haemodyalisis patients: effects of vitamin E supplementation
M. Elli;
1989
Abstract
In haemodialysis patients, increased concentrations of malonyldialdehyde and decreased vitamin E content indicate lipid peroxidation in the platelets from oxidative damage. The same process has been described in red blood cells and in mononuclear cells in peripheral blood. However, platelet aggregation is within normal limits and does not change after treatment with vitamin E. On the other hand vitamin E supplementation reverts completely the biochemical abnormality of the platelets.
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