Fluoroquinolones, fully synthetic antibacterial compounds, have been used therapeutically for over 30 years and represent a major class of antibacterial with a great therapeutic potential. In this first part of the review we examine the main synthetic approaches for the preparation of antibacterial quinolones, including their aza analogues (4-oxonaphtyridine and 4-oxocinnoline derivatives). Condensed polycyclic analogues (tricyclic and tetracyclic compounds) are, also, examined.
Antibacterial quinolones. Part 1. Synthesis / C.M. Passarotti, M. Valenti, D. Passarella, M. Martinelli. - In: BOLLETTINO CHIMICO FARMACEUTICO. - ISSN 0006-6648. - 138:7(1999), pp. 311-331.
Antibacterial quinolones. Part 1. Synthesis
D. PassarellaPenultimo
;
1999
Abstract
Fluoroquinolones, fully synthetic antibacterial compounds, have been used therapeutically for over 30 years and represent a major class of antibacterial with a great therapeutic potential. In this first part of the review we examine the main synthetic approaches for the preparation of antibacterial quinolones, including their aza analogues (4-oxonaphtyridine and 4-oxocinnoline derivatives). Condensed polycyclic analogues (tricyclic and tetracyclic compounds) are, also, examined.
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