The acute effects of ethanol (0.5 ml/kg b.w.) and caffeine (200 mg), alone or in combination, on platelet function and plasma lipid-lipoprotein levels, were tested in four healthy volunteers according to a Latin Square design. The effects of ethanol alone on platelet function (adrenaline- and collagen-induced aggregation, thromboxane B2 formation induced by arachidonic acid) were negligible. Conversely, caffeine significantly reduced maximal aggregation of platelets following adrenaline and collagen, 3 hours after administration; it also significantly increased thromboxane B2 formation 1 hour from administration. The intakes of caffeine and, to some extent, of ethanol at doses in the common daily range, although not profoundly affecting platelet function or lipid parameters, should be given consideration when treatments with platelet-active drugs are prescribed.

Acute effects of ethanol, caffeine, or both on platelet aggregation, thromboxane formation, and plasma-free fatty acids in normal subjects / C. Galli, S. Colli, G. Gianfranceschi, P. Maderna, A. Petroni, E. Tremoli, M. Marinovich, C.R. Sirtori. - In: DRUG-NUTRIENT INTERACTIONS. - ISSN 0272-3530. - 3:1(1984), pp. 61-67.

Acute effects of ethanol, caffeine, or both on platelet aggregation, thromboxane formation, and plasma-free fatty acids in normal subjects

C. Galli;S. Colli;A. Petroni;E. Tremoli;M. Marinovich;C.R. Sirtori
1984

Abstract

The acute effects of ethanol (0.5 ml/kg b.w.) and caffeine (200 mg), alone or in combination, on platelet function and plasma lipid-lipoprotein levels, were tested in four healthy volunteers according to a Latin Square design. The effects of ethanol alone on platelet function (adrenaline- and collagen-induced aggregation, thromboxane B2 formation induced by arachidonic acid) were negligible. Conversely, caffeine significantly reduced maximal aggregation of platelets following adrenaline and collagen, 3 hours after administration; it also significantly increased thromboxane B2 formation 1 hour from administration. The intakes of caffeine and, to some extent, of ethanol at doses in the common daily range, although not profoundly affecting platelet function or lipid parameters, should be given consideration when treatments with platelet-active drugs are prescribed.
Thromboxanes ; Platelet Aggregation ; Fatty Acids, Nonesterified ; Humans ; Thromboxane B2 ; Adult ; Caffeine ; Male ; Ethanol
Settore BIO/14 - Farmacologia
Settore BIO/10 - Biochimica
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/193601
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 16
  • ???jsp.display-item.citation.isi??? ND
social impact