Forty-two male rats were injected with a single intraperitoneal dose of TCDD in acetone and corn oil and sacrificed after 2, 4, 8, 16, 24, and 32 weeks, to study the long-term effects of a single injection. The liver lesions become progressively worse up to the 16th week and appear thereafter to slowly regress.
Natural history of TCDD-induced liver lesions in rats as observed by transmission electron microscopy during a 32-week period after a single intraperitoneal injection / G. Weber, P. Luzi, L. Resi, P. Tanganelli, M. R. Lovati, A. Poli. - In: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH. - ISSN 0098-4108. - 12:4-6(1983), pp. 533-540.
|Titolo:||Natural history of TCDD-induced liver lesions in rats as observed by transmission electron microscopy during a 32-week period after a single intraperitoneal injection|
LOVATI, MARIA ROSA (Penultimo)
|Parole Chiave:||Tetrachlorodibenzodioxin; Rats, Inbred Strains; Rats; Injections, Intraperitoneal; Animals; Liver; Microscopy, Electron; Time Factors; Male; Dioxins|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1983|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1080/15287398309530447|
|Appare nelle tipologie:||01 - Articolo su periodico|