BACKGROUND: T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) primarily presenting on the skin is an extremely rare entity with only sporadic cases reported in the literature. METHODS: We here report an extraordinary case of primary cutaneous THRLBCL with self-healing and 24 months of follow-up. RESULTS: The lesion was a dermohypodermal/subcutaneous circumscribed ulcerated nodosity. Histological examination with immunohistochemical, molecular analysis and comparative genomic hybridization were performed. A complete staging was negative for secondary involvement. CONCLUSION: Our case is remarkable because it is the second well-documented primary cutaneous THRLBCL in which we observed a complete self-regression of skin lesions without recurrences or dissemination of the disease. According to the literature, we highlight that the tumoral microenvironment, in our case, could play a relevant role in stopping lymphoma growth. Furthermore, this case supports the observation that THRLBCL primarily presenting on the skin shows an overall good prognosis.

Cutaneous T-cell/histiocyte-rich B-cell lymphoma: a case report and review of the literature / P. Vezzoli, R. Fiorani, V. Girgenti, D. Fanoni, S. Tavecchio, Y. Balice, R. Mozzana, C. Crosti, E. Berti. - In: DERMATOLOGY. - ISSN 1018-8665. - 222:3(2011), pp. 225-230. [10.1159/000327376]

Cutaneous T-cell/histiocyte-rich B-cell lymphoma: a case report and review of the literature

D. Fanoni;S. Tavecchio;Y. Balice;C. Crosti
Penultimo
;
E. Berti
2011

Abstract

BACKGROUND: T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) primarily presenting on the skin is an extremely rare entity with only sporadic cases reported in the literature. METHODS: We here report an extraordinary case of primary cutaneous THRLBCL with self-healing and 24 months of follow-up. RESULTS: The lesion was a dermohypodermal/subcutaneous circumscribed ulcerated nodosity. Histological examination with immunohistochemical, molecular analysis and comparative genomic hybridization were performed. A complete staging was negative for secondary involvement. CONCLUSION: Our case is remarkable because it is the second well-documented primary cutaneous THRLBCL in which we observed a complete self-regression of skin lesions without recurrences or dissemination of the disease. According to the literature, we highlight that the tumoral microenvironment, in our case, could play a relevant role in stopping lymphoma growth. Furthermore, this case supports the observation that THRLBCL primarily presenting on the skin shows an overall good prognosis.
Cutaneous presentation; T-cell/histiocyte-rich B-cell lymphoma; Tumoral microenvironment
Settore MED/35 - Malattie Cutanee e Veneree
2011
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/191155
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