BACKGROUND: T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) primarily presenting on the skin is an extremely rare entity with only sporadic cases reported in the literature. METHODS: We here report an extraordinary case of primary cutaneous THRLBCL with self-healing and 24 months of follow-up. RESULTS: The lesion was a dermohypodermal/subcutaneous circumscribed ulcerated nodosity. Histological examination with immunohistochemical, molecular analysis and comparative genomic hybridization were performed. A complete staging was negative for secondary involvement. CONCLUSION: Our case is remarkable because it is the second well-documented primary cutaneous THRLBCL in which we observed a complete self-regression of skin lesions without recurrences or dissemination of the disease. According to the literature, we highlight that the tumoral microenvironment, in our case, could play a relevant role in stopping lymphoma growth. Furthermore, this case supports the observation that THRLBCL primarily presenting on the skin shows an overall good prognosis.
Cutaneous T-cell/histiocyte-rich B-cell lymphoma: a case report and review of the literature / P. Vezzoli, R. Fiorani, V. Girgenti, D. Fanoni, S. Tavecchio, Y. Balice, R. Mozzana, C. Crosti, E. Berti. - In: DERMATOLOGY. - ISSN 1018-8665. - 222:3(2011), pp. 225-230.
|Titolo:||Cutaneous T-cell/histiocyte-rich B-cell lymphoma: a case report and review of the literature|
CROSTI, CARLO (Penultimo)
|Parole Chiave:||Cutaneous presentation; T-cell/histiocyte-rich B-cell lymphoma; Tumoral microenvironment|
|Settore Scientifico Disciplinare:||Settore MED/35 - Malattie Cutanee e Veneree|
|Data di pubblicazione:||2011|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1159/000327376|
|Appare nelle tipologie:||01 - Articolo su periodico|