Green tea catechins were given to healthy volunteers under controlled diet for 4 consecutive weeks. Plasma concentrations of ascorbate, urate, -tocopherol, -carotene and blood levels of total glutathione were measured before, after the supplementation and the wash-out period. RBC membranes were assayed for their levels of -tocopherol and phosphatidylcholine PUFA’s. Catechin intake provides antioxidant protection in vivo through a cascade involving endogenous antioxidants, which interact differently according to their redox potentials and polarity. As a final beneficial effect, liposoluble vitamin E and -carotene are spared by catechins, resulting in an overall protection against oxidative modification of RBC membrane PUFA’s.

DIETARY FLAVONOIDS AND INTERACTION WITH ENDOGENOUS ANTIOXIDANTS / P.G. Pietta, P. Simonetti. - In: BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL. - ISSN 1039-9712. - 44:5(1998), pp. 1069-1074.

DIETARY FLAVONOIDS AND INTERACTION WITH ENDOGENOUS ANTIOXIDANTS

P. Simonetti
Ultimo
1998

Abstract

Green tea catechins were given to healthy volunteers under controlled diet for 4 consecutive weeks. Plasma concentrations of ascorbate, urate, -tocopherol, -carotene and blood levels of total glutathione were measured before, after the supplementation and the wash-out period. RBC membranes were assayed for their levels of -tocopherol and phosphatidylcholine PUFA’s. Catechin intake provides antioxidant protection in vivo through a cascade involving endogenous antioxidants, which interact differently according to their redox potentials and polarity. As a final beneficial effect, liposoluble vitamin E and -carotene are spared by catechins, resulting in an overall protection against oxidative modification of RBC membrane PUFA’s.
α-tocopherol; β-carotene; Ascorbate; Endogenous antioxidants; Green tea catechins; PUFA's protection; Redox potentials; Sparing effect
Settore BIO/09 - Fisiologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/190827
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