An EPA enriched oil (MaxEPA, Seven Seas, U.K. containing 18% EPA and 12% DHA) alone or supplemented with 10 mg/ml/alpha tocopherol, was administered by gastric intubation at the dose of 3.2 ml/kg/day for a period of eight weeks to male rats fed a standard diet. An additional group of animals was treated with the same amount of olive oil. The administration of MaxEPA alone resulted, as expected, in accumulation of EPA and reduction of AA levels in plasma, platelet, red blood cell and PMNL phospholipids, when compared to values in the olive oil group. In addition, levels of linoleic acid were elevated, suggesting inhibition of the conversion of linoleic to arachidonic acid. Formation of i.r. TxB2 by stimulated PRP, of i.r. 6-keto-PGF1 alpha by perfused aortas, and of IR LTB4 and C4 by stimulated PMNL were reduced, but production of superoxide anion by PMNL was enhanced by MaxEPA treatment vs the olive oil treatment. Supplementation of MaxEPA with vitamin E caused a smaller reduction of 20:4 levels and a smaller increase of 20:5 levels in plasma and cell phospholipids and modified the effects of MaxEPA on eicosanoid and superoxide anion production, suggesting that lipid peroxidation may mediate some of the biological effects of omega 3 fatty acids.
Vitamin E influences the effects of fish oil on fatty acids and eicosanoid production in plasma and circulating cells in the rat / C. Mosconi, S. Colli, L. Medini, E. Stragliotto, P. Maderna, E. Tremoli, C. Galli. - In: BIOCHEMICAL PHARMACOLOGY. - ISSN 0006-2952. - 37:18(1988 Sep 15), pp. 3415-3421.
|Titolo:||Vitamin E influences the effects of fish oil on fatty acids and eicosanoid production in plasma and circulating cells in the rat|
|Parole Chiave:||Animals ; Thromboxanes ; Lipids ; Eicosapentaenoic Acid ; Prostaglandins ; Fatty Acids ; Superoxides ; Blood Cells ; Plant Oils ; Rats ; Vitamin E ; Fish Oils ; Dietary Fats ; Male|
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
|Data di pubblicazione:||15-set-1988|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0006-2952(88)90690-9|
|Appare nelle tipologie:||01 - Articolo su periodico|