The development and validation, by experimental design, of an adsorptive stripping voltammetric procedure for nimesulide determination is described. A Plackett-Burman matrix and a Doehlert design were used for the screening step and response surface study, respectively. Response surface evaluation allowed the method to be defined robust and robustness testing was considered unnecessary. A full factorial design was employed for intermediate precision determination according to ICH guidelines. Applying the optimised conditions, the linear range was 3.32 x 10(-9)-3.85 x 10(-7) M and the dosage form mean recovery was 101.3% with RSD of 1.3% (n=9). (C) 2000 Elsevier Science B.V. All rights reserved.
|Titolo:||Designing experiments to optimise and validate the adsorptive stripping voltammetric determination of nimesulide|
|Parole Chiave:||Adsorptive stripping voltammetry; Dosage form; Experimental design; Nimesulide determination; Validation|
|Settore Scientifico Disciplinare:||Settore CHIM/08 - Chimica Farmaceutica|
Settore CHIM/01 - Chimica Analitica
|Data di pubblicazione:||2000|
|Digital Object Identifier (DOI):||10.1016/S0003-2670(00)00735-2|
|Appare nelle tipologie:||01 - Articolo su periodico|