The development and validation, by experimental design, of an adsorptive stripping voltammetric procedure for nimesulide determination is described. A Plackett-Burman matrix and a Doehlert design were used for the screening step and response surface study, respectively. Response surface evaluation allowed the method to be defined robust and robustness testing was considered unnecessary. A full factorial design was employed for intermediate precision determination according to ICH guidelines. Applying the optimised conditions, the linear range was 3.32 x 10(-9)-3.85 x 10(-7) M and the dosage form mean recovery was 101.3% with RSD of 1.3% (n=9). (C) 2000 Elsevier Science B.V. All rights reserved.

Designing experiments to optimise and validate the adsorptive stripping voltammetric determination of nimesulide / S. Furlanetto, S. Orlandini, G. Aldini, R. Gotti, E. Dreassi, S. Pinzauti. - In: ANALYTICA CHIMICA ACTA. - ISSN 0003-2670. - 413:1-2(2000), pp. 229-239. [10.1016/S0003-2670(00)00735-2]

Designing experiments to optimise and validate the adsorptive stripping voltammetric determination of nimesulide

G. Aldini;
2000

Abstract

The development and validation, by experimental design, of an adsorptive stripping voltammetric procedure for nimesulide determination is described. A Plackett-Burman matrix and a Doehlert design were used for the screening step and response surface study, respectively. Response surface evaluation allowed the method to be defined robust and robustness testing was considered unnecessary. A full factorial design was employed for intermediate precision determination according to ICH guidelines. Applying the optimised conditions, the linear range was 3.32 x 10(-9)-3.85 x 10(-7) M and the dosage form mean recovery was 101.3% with RSD of 1.3% (n=9). (C) 2000 Elsevier Science B.V. All rights reserved.
Adsorptive stripping voltammetry; Dosage form; Experimental design; Nimesulide determination; Validation
Settore CHIM/08 - Chimica Farmaceutica
Settore CHIM/01 - Chimica Analitica
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/187618
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 63
  • ???jsp.display-item.citation.isi??? 58
social impact